Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/197
Title: Circadian Dysfunction Reduces Lifespan In Drosophila Melanogaster
Authors: Kumar, Shailesh
Mohan, Ambika
Sharma, Vijay Kumar
Keywords: circadian clock
Drosophila
activity/rest
circadian dysfunction
lifespan
Sleep-Deprivation
Locomotor-Activity
Time-Series
Longevity
Rhythm
Genes
Periodicity
Homeostasis
Mutations
Fitness
Issue Date: 2005
Publisher: Taylor & Francis Inc
Citation: Chronobiology International 22(4), 641-653 (2005)
Abstract: Circadian clocks regulate physiological and behavioral processes in a wide variety of organisms, and any malfunction in these clocks can cause significant health problems. In this paper, we report the results of our study on the physiological consequences of circadian dysfunction (malfunctioning of circadian clocks) in two wild-type populations of fruit flies (Drosophila melanogaster). We assayed locomotor activity behavior and lifespan among adult flies kept nuclei, constant dark (DD) conditions of the laboratory, wherein they were categorized as rhythmic if their activity/rest schedules followed circadian (approximately 24h) patterns, and as arrhythmic if their activity/rest schedules did not display any pattern. The rhythmic flies front both populations lived significantly longer than the arrhythmic ones. Based on these results, we conclude that circadian dysfunction is deleterious, and proper functioning of circadian clocks is essential for the physiological well being of D. melanogaster.
Description: Restricted Access
URI: https://libjncir.jncasr.ac.in/xmlui/10572/197
Other Identifiers: 0742-0528
Appears in Collections:Research Articles (V. K. Sharma)

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