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https://libjncir.jncasr.ac.in/xmlui/handle/10572/197
Title: | Circadian Dysfunction Reduces Lifespan In Drosophila Melanogaster |
Authors: | Kumar, Shailesh Mohan, Ambika Sharma, Vijay Kumar |
Keywords: | circadian clock Drosophila activity/rest circadian dysfunction lifespan Sleep-Deprivation Locomotor-Activity Time-Series Longevity Rhythm Genes Periodicity Homeostasis Mutations Fitness |
Issue Date: | 2005 |
Publisher: | Taylor & Francis Inc |
Citation: | Chronobiology International 22(4), 641-653 (2005) |
Abstract: | Circadian clocks regulate physiological and behavioral processes in a wide variety of organisms, and any malfunction in these clocks can cause significant health problems. In this paper, we report the results of our study on the physiological consequences of circadian dysfunction (malfunctioning of circadian clocks) in two wild-type populations of fruit flies (Drosophila melanogaster). We assayed locomotor activity behavior and lifespan among adult flies kept nuclei, constant dark (DD) conditions of the laboratory, wherein they were categorized as rhythmic if their activity/rest schedules followed circadian (approximately 24h) patterns, and as arrhythmic if their activity/rest schedules did not display any pattern. The rhythmic flies front both populations lived significantly longer than the arrhythmic ones. Based on these results, we conclude that circadian dysfunction is deleterious, and proper functioning of circadian clocks is essential for the physiological well being of D. melanogaster. |
Description: | Restricted Access |
URI: | https://libjncir.jncasr.ac.in/xmlui/10572/197 |
Other Identifiers: | 0742-0528 |
Appears in Collections: | Research Articles (V. K. Sharma) |
Files in This Item:
File | Description | Size | Format | |
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2005 Chronobiology International 22 641–653.pdf Restricted Access | 397.47 kB | Adobe PDF | View/Open Request a copy |
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