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https://libjncir.jncasr.ac.in/xmlui/handle/10572/1992| Title: | A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans |
| Authors: | Varshney, Neha Schaekel, Alida Singha, Rima Chakraborty, Tanmoy van Wijlick, Lasse Ernst, Joachim F. Sanyal, Kaustuv |
| Keywords: | Genetics & Heredity kinase Sch9 centromere chromosome segregation kinetochore Yeast Saccharomyces-Cerevisiae Kinetochore Gene Efficient Transmission Centromeres Longevity Chromatin Homolog MCM21 |
| Issue Date: | 2015 |
| Publisher: | Genetics Society of America |
| Citation: | Genetics 199 3 Varshney, N.; Schaekel, A.; Singha, R.; Chakraborty, T.; van Wijlick, L.; Ernst, J. F.; Sanyal, K., A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans. Genetics 2015, 199 (3), 671-+. |
| Abstract: | The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation. |
| Description: | Restricted access |
| URI: | https://libjncir.jncasr.ac.in/xmlui/10572/1992 |
| ISSN: | 0016-6731 |
| Appears in Collections: | Research Papers (Kaustuv Sanyal) |
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