Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/2011
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dc.contributor.authorYarlagadda, Venkateswarlu
dc.contributor.authorSarkar, Paramita
dc.contributor.authorManjunath, Goutham B.
dc.contributor.authorHaldar, Jayanta
dc.date.accessioned2017-01-04T09:09:00Z-
dc.date.available2017-01-04T09:09:00Z-
dc.date.issued2015
dc.identifier.citationBioorganic & Medicinal Chemistry Lettersen_US
dc.identifier.citation25en_US
dc.identifier.citation23en_US
dc.identifier.citationYarlagadda, V.; Sarkar, P.; Manjunath, G. B.; Haldar, J., Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria. Bioorganic & Medicinal Chemistry Letters 2015, 25 (23), 5477-5480.en_US
dc.identifier.issn0960-894X
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/10572/2011-
dc.descriptionRestricted accessen_US
dc.description.abstractAntibiotic-resistant superbugs such as vancomycin-resistant Enterococci (VRE) and Staphylococci have become a major global health hazard. To address this issue, we synthesized vancomycin aglycon dimers to systematically probe the impact of a linker on biological activity. A dimer having a pendant lipophilic moiety in the linker showed similar to 300-fold more activity than vancomycin against VRE. The high activity of the compound is attributed to its enhanced binding affinity to target peptides which resulted in improved peptidoglycan (cell wall) biosynthesis inhibition. Therefore, our studies suggest that these compounds, prepared by using facile synthetic methodology, can be used to combat vancomycin-resistant bacterial infections. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.uri1464-3405en_US
dc.description.urihttp://dx.doi.org/10.1016/j.bmcl.2015.10.083en_US
dc.language.isoEnglishen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.rights?Pergamon-Elsevier Science Ltd, 2015en_US
dc.subjectMedicinal Chemistryen_US
dc.subjectChemistry, Organicen_US
dc.subjectAntibiotic resistanceen_US
dc.subjectVancomycinen_US
dc.subjectVancomycin-resistant bacteriaen_US
dc.subjectCell wall biosynthesis inhibitionen_US
dc.subjectAntibacterial activityen_US
dc.subjectALA-D-LACen_US
dc.subjectGlycopeptide Antibiotic-Activityen_US
dc.subjectIn-Vivo Efficacyen_US
dc.subjectPharmacological-Propertiesen_US
dc.subjectAntibacterial Activityen_US
dc.subjectStaphylococcus-Aureusen_US
dc.subjectDerivativesen_US
dc.subjectEnterococcien_US
dc.subjectDiscoveryen_US
dc.subjectBindingen_US
dc.titleLipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteriaen_US
dc.typeArticleen_US
Appears in Collections:Research Papers (Jayanta Haldar)

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