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dc.contributor.authorPadiath, Quasar Saleem-
dc.contributor.authorParanjpe, Dhanashree-
dc.contributor.authorJain, Sanjeev-
dc.contributor.authorSharma, Vijay Kumar-
dc.date.accessioned2012-01-20T09:48:31Z-
dc.date.available2012-01-20T09:48:31Z-
dc.date.issued2004-
dc.identifier0742-0528en_US
dc.identifier.citationChronobiology International 21(1), 43-55 (2004)en_US
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/10572/224-
dc.descriptionRestricted Accessen_US
dc.description.abstractAlthough lithium is one of the most commonly used drugs in the prophylaxis and treatment or bipolar disorder, the mechanisms Underlying its therapeutic action are still unclear. Together with its mood-stabilizing effects, lithium is also known to influence the circadian clocks of several organisms ncluding man. Circadian rhythms are altered in patients with bipolar disorder, and it is believed that these rhythms may play an important role in disease mechanisms. It is therefore possible that some of the therapeutic actions of lithium may be related to its effect on circadian clocks. Identifying the targets for lithium's action on circadian clocks would therefore be important both for understanding the mechanisms of its therapeutic effect and also in further understanding disease mechanisms in bipolar disorders. Using Drosophila melanogaster as a model system, we show that long-term administration of lithium results in lengthening of the free-running period (tau) of circadian locomotor activity rhythm of flies in constant darkness (DD). This effect occurs at concentrations similar to the plasma levels of lithium used in the treatment of bipolar disorder. The lithium-treated flies also show reduced activity of one of the previously reported targets of lithium action, Glycogen Synthase Kinase 3beta (GSK 3beta). GSK 3beta has been shown to be involved in the regulation of circadian clocks as the down regulation of this protein results in an elongation of tau. The tau elongation resembles the effect seen with lithium administration in a number of organisms including man, and taken together with the earlier observations our results suggest that lithium inhibits the activity of GSK 3beta to produce its effect on circadian clocks.en_US
dc.description.urihttp://dx.doi.org/10.1081/CBI-120027981en_US
dc.language.isoenen_US
dc.publisherMarcel Dekker Incen_US
dc.rights© 2004 Marcel Dekker Incen_US
dc.subjectlithiumen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectcircadian rhythmsen_US
dc.subjectGSK 3 betaen_US
dc.subjectperiod elongationen_US
dc.subjectBipolar Disorderen_US
dc.subjectDrosophila-Melanogasteren_US
dc.subjectSignaling Pathwayen_US
dc.subjectPhase Advanceen_US
dc.subjectMechanismen_US
dc.subjectWnt-7aen_US
dc.subjectComponentsen_US
dc.subjectTherapyen_US
dc.subjectNeuronsen_US
dc.subjectRhythmsen_US
dc.titleGlycogen Synthase Kinase 3b as a Likely Target for the Action of Lithium on Circadian Clocksen_US
dc.typeArticleen_US
Appears in Collections:Research Articles (V. K. Sharma)

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