Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/2331
Title: Gene regulatory networks and epigenetic modifications in cell differentiation
Authors: Roy, Siddhartha
Kundu, Tapas Kumar
Keywords: Biochemistry & Molecular Biology
Cell Biology
Transcription Factors
Gene Regulatory Network
Cell Differentiation
Epigenetic Modification
Multistationarity
Embryonic Stem-Cells
Multiple Stationary States
Chemical-Reaction Network
Lineage-Commitment
Relative Stability
Escherichia-Coli
Progenitor Cells
Transcription
Hematopoiesis
Pluripotency
Issue Date: 2014
Publisher: Wiley-Blackwell
Citation: Roy, S; Kundu, TK, Gene regulatory networks and epigenetic modifications in cell differentiation. IUBMB Life 2014, 66 (2) 100-109, http://dx.doi.org/10.1002/iub.1249
IUBMB Life
66
2
Abstract: It is becoming increasingly clear that the functionalities of an organism are mostly derived from regulation of its gene repertoire. Specialized cell types are created from pluripotent stem cells by regulating expression of genes. In eukaryotes, genes are primarily regulated by gene regulatory networks consisting of highly sequence-specific transcription factors and epigenetic modifications. The former mode of regulation is more readily reversible and non-heritable across cell generations, whereas the latter mode is less reversible and heritable. In this article, we explore the relationship between cell differentiation and the two modes of regulation of gene expression, focusing primarily on pluripotent and multipotent stem cells. Recent studies suggest that stem cells execute different gene expression programs, probably driven by one or more gene regulatory network(s). It is now also evident that as stem cells differentiate to more specialized progeny cells, rewriting of epigenetic marks occurs in parallel with the change in the pattern of gene expression. A conceptual framework is put forward in which it is proposed that the cell fate determining gene regulatory network in a pluripotent or multipotent cell has the capability to exist in multiple stationary states with each stationary state dictating a particular pattern of gene expression. We also propose that the broad pattern of gene expression in each stationary state, termed the lineage biased state or LIBS, resembles that of a more differentiated progeny cell. The differentiation process leading to a particular progeny cell involves rewriting of epigenetic marks that result in upregulation of genes in a LIBS and silencing of genes involved in alternative LIBS; thus selecting a particular pattern of gene expression and making a lineage commitment. (c) 2014 IUBMB Life, 66(2):100-109, 2014
Description: Restricted Access
URI: https://libjncir.jncasr.ac.in/xmlui/10572/2331
ISSN: 1521-6543
Appears in Collections:Research Papers (Tapas K. Kundu)

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