Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/2489
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dc.contributor.authorRajasekhar, Kolla
dc.contributor.authorNarayanaswamy, Nagarjun
dc.contributor.authorMishra, Piyush
dc.contributor.authorSuresh, S. N.
dc.contributor.authorManjithaya, Ravi
dc.contributor.authorGovindaraju, T.
dc.date.accessioned2017-02-21T08:56:26Z-
dc.date.available2017-02-21T08:56:26Z-
dc.date.issued2014
dc.identifier.citationRajasekhar, K; Narayanaswamy, N; Mishra, P; Suresh, SN; Manjithaya, R; Govindaraju, T, Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer. Chempluschem 2014, 79 (1) 25-30, http://dx.doi.org/10.1002/cplu.201300343en_US
dc.identifier.citationChempluschemen_US
dc.identifier.citation79en_US
dc.identifier.citation1en_US
dc.identifier.issn2192-6506
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/10572/2489-
dc.descriptionRestricted Accessen_US
dc.description.abstractCyclic peptoids are potential candidates for diverse biological activities. However, applications of cyclic peptoids are limited by the synthetic difficulties, conformational flexibility of large cyclic peptoids, and lack of secondary amide in the backbone. Herein, an elegant methodology for the synthesis of small and medium-size cyclic hybrid peptoids is developed. N-alpha-Alkyl and N-alpha-acyl substituents in N-(2-aminoethyl) glycine monomers enforce intra-and intermolecular cyclization to form stable six-and 12-membered cyclic products, respectively. NMR studies show inter-and intramolecular hydrogen bonding in six-and 12-membered cyclic peptoids, respectively. Screening of a cyclic peptoid library resulted in the identification of a potential candidate that enhanced autophagic degradation of cargo in a live cell model. Such upregulation of autophagy using small molecules is a promising approach for elimination of intracellular pathogens and neurodegenerative protein aggregates.en_US
dc.description.urihttp://dx.doi.org/10.1002/cplu.201300343en_US
dc.language.isoEnglishen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.rights@Wiley-V C H Verlag Gmbh, 2014en_US
dc.subjectChemistryen_US
dc.subjectRelative Cell-Permeabilityen_US
dc.subjectAlpha-Peptoidsen_US
dc.subjectPeptidesen_US
dc.subjectPeptidomimeticsen_US
dc.subjectCyclizationen_US
dc.subjectDiscoveryen_US
dc.titleSynthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhanceren_US
dc.typeArticleen_US
Appears in Collections:Research Papers (Govindaraju, T.)
Research Papers (Ravi Manjithaya)

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