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Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/2599
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dc.contributor.authorGodbole, Adwait Anand
dc.contributor.authorAhmed, Wareed
dc.contributor.authorBhat, Rajeshwari Subray
dc.contributor.authorBradley, Erin K.
dc.contributor.authorEkins, Sean
dc.contributor.authorNagaraja, V.
dc.date.accessioned2017-02-21T09:53:24Z-
dc.date.available2017-02-21T09:53:24Z-
dc.date.issued2014
dc.identifier.citationGodbole, AA; Ahmed, W; Bhat, RS; Bradley, EK; Ekins, S; Nagaraja, V, Inhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poison. Biochemical And Biophysical Research Communications 2014, 446 (4) 916-920, http://dx.doi.org/10.1016/j.bbrc.2014.03.029en_US
dc.identifier.citationBiochemical And Biophysical Research Communicationsen_US
dc.identifier.citation446en_US
dc.identifier.citation4en_US
dc.identifier.issn0006-291X
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/10572/2599-
dc.descriptionRestricted Accessen_US
dc.description.abstractm-AMSA, an established inhibitor of eukaryotic type II topoisomerases, exerts its cidal effect by binding to the enzyme-DNA complex thus inhibiting the DNA religation step. The molecule and its analogues have been successfully used as chemotherapeutic agents against different forms of cancer. After virtual screening using a homology model of the Mycobacterium tuberculosis topoisomerase I, we identified m-AMSA as a high scoring hit. We demonstrate that m-AMSA can inhibit the DNA relaxation activity of topoisomerase I from M. tuberculosis and Mycobacterium smegmatis. In a whole cell assay, m-AMSA inhibited the growth of both the mycobacteria. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.uri1090-2104en_US
dc.description.urihttp://dx.doi.org/10.1016/j.bbrc.2014.03.029en_US
dc.language.isoEnglishen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.rights@Academic Press Inc Elsevier Science, 2014en_US
dc.subjectBiochemistry & Molecular Biologyen_US
dc.subjectBiophysicsen_US
dc.subjectM-Amsaen_US
dc.subjectType I Topoisomeraseen_US
dc.subjectMycobacterium Tuberculosisen_US
dc.subjectTopoisomerase Inhibitorsen_US
dc.subjectDNA Topoisomerasesen_US
dc.subjectAnticancer Drugsen_US
dc.subjectCleavageen_US
dc.subjectMechanismen_US
dc.subjectGyraseen_US
dc.subjectComplexen_US
dc.subjectEnzymeen_US
dc.subjectReligationen_US
dc.subjectAmsacrineen_US
dc.subjectLeukemiaen_US
dc.titleInhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poisonen_US
dc.typeArticleen_US
Appears in Collections:Research Articles (Nagaraja, V.)

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