Bacterial membrane-targeting cationic-amphiphilic polymers that combat antibiotic resistance and neutralize endotoxins

Abstract

Infectious diseases continue to cause high mortality in global population and are the biggest threat for public health1. Infectious diseases contribute for nearly 15 million global deaths every year1, 2. The infectious disease burden in India is among the highest in the world3. Antimicrobial resistance (AMR) has worsened the global threat of infectious diseases. AMR causes an estimated 700,000 deaths annually and is predicted to cause 10 million deaths annually by 2050. AMR, if left unchecked, will increase the worldwide healthcare costs to $100 trillion by 20504,5.