Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/2672
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorGovindaraju, T.-
dc.contributor.authorRajasekhar, K.-
dc.date.accessioned2019-07-18T11:21:33Z-
dc.date.available2019-07-18T11:21:33Z-
dc.date.issued2017-
dc.identifier.citationRajasekhar, K. 2017, Design, synthesis and study of molecular probes for diagnostic and therapeutic applications in Alzheimer's disease, Ph.D thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluruen_US
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/handle/10572/2672-
dc.description.abstract"The process of protein misfolding and aggregation has been a prime subject of research. This process is identified in the main pathological event involved in several diseases like Alzheimer’s disease (AD), Parkinson disease (PD), Huntington disease (HD), Type II diabetes (T2D) and prion-related disorders among others.1-3 AD is the most prevalent form of neurodegenerative diseases causing progressive attrition of cognition, task performance ability, mood, speech, behaviour and memory.4,5,6 A recent report from the National Center for Health Statistics (NCHS), USA suggests that deaths caused by diseases like ischemic heart disease, brain stroke, AIDS (acquired immune deficiency syndrome) and cancer have decreased significantly, while deaths caused by AD is on a constant rise.7 Alarmingly, in the next decade AD is likely to become particularly devastating for the poor and developing countries, severely affecting their public health and economy.8 For this reason, both scientific and clinical research community is putting tremendous efforts into understanding the disease to develop molecular tools for early diagnosis and cure. AD involves two major types of misfolded protein aggregates: intracellular aggregates of the microtubule-associated tau protein (called neurofibrillary tangles - NFT) and extracellular peptide aggregates known as senile plaques, mainly composed of amyloid  (Aβ) peptides.9 Aβ peptides are transmembrane peptides produced by incorrect processing of the integral membrane protein called amyloid precursor protein (APP).10 The physiological function of Aβ peptide in normal brain is not completely understood, although it is said to be playing a vital role in neurogenesis and modulation of synaptic plasticity.11"en_US
dc.language.isoEnglishen_US
dc.publisherJawaharlal Nehru Centre for Advanced Scientific Researchen_US
dc.rights© 2017 JNCASR-
dc.subjectAlzheimer diseaseen_US
dc.titleDesign, synthesis and study of molecular probes for diagnostic and therapeutic applications in Alzheimer's diseaseen_US
dc.typeThesisen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePh.D.en_US
dc.publisher.departmentNew Chemistry Unit (NCU)en_US
Appears in Collections:Student Theses (NCU)

Files in This Item:
File SizeFormat 
9474.pdf15.96 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.