Development of cationic lipophilic vancomycin analogues against bacterial biofilms and intracellular pathogens

Abstract

Bacterial infectious diseases: A growing global health concern With the emergence of antimicrobial resistance, infectious diseases have been proclaimed as one of the greatest threats to global human health by the World Health Organization (WHO).1 Infectious diseases are caused by microorganisms such as bacteria, viruses, fungi and parasites and spread, directly or indirectly, from one person to another. Globally, infectious diseases caused by bacteria contribute to approximately 20 % of overall burden of infectious diseases. India is a hotspot for infectious diseases, occupying the highest position for the occurrence of bacterial infections in the world.