Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/2801
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dc.contributor.advisorBalaram, Hemalatha-
dc.contributor.authorShivakumaraswamy, Santosh-
dc.date.accessioned2019-11-06T05:16:57Z-
dc.date.available2019-11-06T05:16:57Z-
dc.date.issued2019-
dc.identifier.citationShivakumaraswamy, Santosh. 2019, Mechanistic underpinnings of substrate recognition, catalysis and allostery in GMP synthetases, Ph.D thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru-
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/handle/10572/2801-
dc.description.abstractThis chapter introduces the reader to the glutamine amidotransferase (GAT) family of enzymes. A brief overview of the reaction catalyzed by these enzymes and the highlights of functioning are presented. This is followed by a summary of the published biochemical and structural information on nine GATs belonging to a sub-family called triad GATs. This includes an in-depth discussion on GMP synthetases (GMPS), a triad GAT investigated in this graduate work. For each enzyme, an attempt is made to highlight the current status in the understanding of various functional aspects. The objectives of this graduate work are laid out in the final section based on the many lacunae that exist in the mechanistic understanding of GMPSs.en_US
dc.language.isoEnglishen_US
dc.publisherJawaharlal Nehru Centre for Advanced Scientific Research-
dc.rights© 2019 JNCASR-
dc.subjectCatalysisen_US
dc.subjectGMP synthetasesen_US
dc.titleMechanistic underpinnings of substrate recognition, catalysis and allostery in GMP synthetasesen_US
dc.typeThesisen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePh.D.en_US
dc.publisher.departmentMolecular Biology and Genetics Unit (MBGU)en_US
Appears in Collections:Student Theses (MBGU)

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