Adenylosuccinate lyase and metabolic fate of fumarate in the intraerythrocytic stages of plasmodium falciparum

Abstract

This chapter gives an introduction on Plasmodium falciparum life cycle and its metabolism. Studying P. falciparum metabolism will not only lead to novel biochemical targets for chemotherapeutic intervention but also stimulate broader scientific interests. Special emphasis is laid on the purine salvage pathway, de novo pyrimidine biosynthetic pathway and the TCA cycle during the asexual stages of the parasite life cycle.