Role of non-histone chromatin protein PC4 in regulation of autophagy and tumorigenesis

Abstract

This chapter introduces the basic concepts of ordered chromatin organization, chromatin dynamics, epigenetics and histone post-translational modifications. The chapter includes a brief review on chromatin organization and the role of non-histone proteins that regulate the dynamicity of the genome. This chapter further focuses on the signal dependent epigenetic language of chromatin and how it modulates several cellular functions and processes like autophagy and DNA damage repair. The chapter will present a comprehensible account of the discovery, functions and the regulation of the non-histone chromatin associated protein PC4