Functional characterization of a subtype-specific NF-kB motif in HIV-1 subtype C viral promoter and its association with the proximal and subtype-specific Sp1site

Abstract

"The retroviruses represent a diverse family of RNA containing viruses. In this family of viruses, the RNA is reverse transcribed into double-stranded DNA which subsequently integrates into the genome of the host cell (Coffin,1992;Lee and Coffin,1990). These viruses have been classified into two groups: simple and complex retroviruses. While the simple retroviruses encode only the critical proteins such as gag, pol and capsid, the complex retroviruses also encode additional regulatory proteins including Tat and rev (Figure-1.1) (Shida,2012)."