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Browsing by Author "Bachu, Mahesh"

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Genetic Diversity in HIV-1 Subtype C LTR from Brazil and Mozambique Generates New Transcription Factor-Binding Sites

Boullosa, Jose; Bachu, Mahesh; Bila, Dulce; Ranga, Udaykumar; Sueffert, Theodoro; Sasazawa, Tomoko; Tanuri, Amilcar (Mdpi Ag, 2014)

The HIV-1 subtype C has been substituting the subtype B population in southern Brazil. This phenomenon has been previously described in other countries, suggesting that subtype C may possess greater fitness than other ...
The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile

Kashi, Venkatesh P.; Jacob, Rajesh A.; Shamanna, Raghavendra A.; Menon, Malini; Balasiddaiah, Anangi; Varghese, Rebu K.; Bachu, Mahesh; Ranga, Udaykumar (Public Library of Science, 2014)

Extracellular Tat (eTat) plays an important role in HIV-1 pathogenesis. The presence of anti-Tat antibodies is negatively correlated with disease progression, hence making Tat a potential vaccine candidate. The cytotoxicity ...
Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes

Dhanasekaran, Karthigeyan; Kumari, Sujata; Boopathi, Ramachandran; Shima, Hiroki; Swaminathan, Amrutha; Bachu, Mahesh; Ranga, Udaykumar; Igarashi, Kazuhiko; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

Positive coactivator 4 (PC4), a human transcriptional coactivator, is involved in diverse processes like chromatin organization and transcription regulation. It is hyperphosphorylated during mitosis, with unknown significance. ...

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