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Browsing by Author "Inamdar, Maneesha S."

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ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis

Khadilkar, Rohan J.; Rodrigues, Diana; Mote, Ridim Dadasaheb; Sinha, Arghyashree Roychowdhury; Kulkarni, Vani; Magadi, Srivathsa Subramanya; Inamdar, Maneesha S. (National Academy of Sciences, 2014)

Drosophila melanogaster larval hematopoiesis is a well-established model to study mechanisms that regulate hematopoietic niche maintenance and control of blood cell precursor (prohemocyte) differentiation. Molecules that ...
Asrij-ARF1 mediated endocytic control of signaling regulates stemness in drosophila hematopoiesis

Khadilkar, Rohan Jayant (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2014)

"Stem cells are unspecialized cells of embryonic, fetal or adult origin, which can give rise to the differentiated and mature cell types in the organism. Their potency to differentiate into different cell types depends ...
Characterization of asrij expression, function and regulation in embryonic stem cells and the developing cardiovascular system

Mukhopadhyay, Arpita (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2005)

This thesis analyses the expression, function and regulation of a novel gene, asrij. The early expression of Asrij allows its use as an embryonic stem- cell marker that is down-regulated in nonvascular tissues. Asrij ...
A conserved role for Asrij in regulating multiple signalling pathways during Drosophila and mouse hematopoiesis

Sinha, Saloni (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2015)

"Studies of hematopoiesis serve as a paradigm for understanding stem cell properties. Stem cells, by definition, are unspecialized cells with the remarkable potential to self-renew as well as give rise to differentiated ...
Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering

Ranganath, Sudhir H.; Tong, Zhixiang; Levy, Oren; Martyn, Keir; Karp, Jeffrey M.; Inamdar, Maneesha S. (Cell Press, 2016)

Mesenchymal stromal cells (MSCs) are promising therapeutic candidates given their potent immunomodulatory and anti-inflammatory secretome. However, controlling the MSC secretome post-transplantation is considered a major ...
Divergent roles of rudhira in maintenance of filtration barrier integrity and function in drosophila nephrocytes and mouse kidney podocytes

Muraleedharan, Simi (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics (MBGU), 2016)

This thesis elucidates the molecular and cellular functions of Rudhira in regulating kidney function using Drosophila and mouse models. Drosophila nephrocytes are the structural and functional homolog of the mammalian ...
Elucidating rudhira function in cytoskeletal organization and TGFB signaling for mouse developmental angiogenesis

Joshi, Divyesh (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2018)

Restricted access
Elucidating the functional link between mitochondrial homeostasis and Drosophila hematopoiesis through mitochondrial AAA+ proteases

Batabyal, Rajarshi (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology & Genetics Unit, 2023-12)

Abstract not available
Elucidating the role of mitochondrial dynamics and endosomal protein sorting in Drosophila blood cell homeostasis

Ray, Arindam (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2021-12)

Blood cell homeostasis depends on the co-ordination of various intracellular and extracellular cues. Sub-cellular organelles play critical roles in post-transcriptional control of signal generation and attenuation. Recently ...
Elucidating the role of Rudhira/BCAS3 in regulating epithelial-mesenchymal transition

Jindal, Preeti (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology & Genetics Unit, 2024-02)

Abstract not available
Elucidation of the conserved role of OCIA domain proteins in regulation of drosophila and mouse blood cell homeostasis

Sinha, Saloni (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2019)

The average human generates over a trillion mature blood cells each day, through a process called hematopoiesis. The bone marrow is the primary site of adult hematopoiesis with minor contributions from the spleen and ...
The endocytic protein Asrij modulates multiple signalling pathways to regulate drosophila hematopoiesis and immunity

Kulkarni, Vani (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2010)

The circulatory/cardiovascular system is the first organ system to develop and function in a vertebrate embryo. The vertebrate cardiovascular system, made up of the heart, blood and the vessels performs the functions of ...
The endocytic protein asrij regulates pluripotency in mouse embryonic stem cells

Sinha, Abhishek (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2013-12-02)

For a long time an intriguing and puzzling aspect in biology is the development of a multicellular organism from a single cell. Mammalian development is carefully organized and orchestrated to transit from a single celled ...
Generation of a constitutively expressing Tetracycline repressor (TetR) human embryonic stem cell line BJNhem20-TetR

Shetty, Ronak; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Human embryonic stem cell line BJNhem20-TetR was generated using non-viral method. The construct pCAG-TetRnls was transfected using microporation procedure. BJNhem20-TetR can subsequently be transfected with any vector ...
Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-20

Shetty, Deeti K.; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Ovarian carcinoma immuno-reactive antigen domain containing 1(OCIAD1) single copy was knocked out generating an OCIAD1 heterozygous knockout human embryonic stem line named BJNhem20-OCIAD1-CRISPR-20. The line was generated ...
Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-39

Shetty, Deeti K.; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Ovarian carcinoma immuno-reactive antigen domain containing 1 (OCIAD1) single copy was knocked out generating an OCIAD1 heterozygous knockout human embryonic stem line named BJNhem20-OCIAD1-CRISPR-39. The line was generated ...
Generation of a transgenic human embryonic stem cell line ectopically expressing the endosomal protein Asrij that regulates pluripotency in mouse embryonic stem cells: BJNhem20-Asrij

Shetty, Deeti K.; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Asrij is an endocytic protein expressed in mouse embryonic stem cells (mESCs) and is essential for maintenance of stemness of mESCs (Mukhopadhyay et al., 2003; Sinha et al., 2013). Its human ortholog named Ovarian Carcinoma ...
Generation of human embryonic stem cell line expressing a red fluorescent protein: BJNhem20-pCAG-tdTomato

Shetty, Deeti K.; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Human embryonic stem cell line BJNhem20-pCAG-tdTomato was generated using non-viral method. The construct pCAG-tdTomato was transfected using microporation procedure. This fluorescent hESC line can help to study heterogeneity ...
Generation of human embryonic stem cell line expressing green fluorescent protein

Shetty, Ronak; Shetty, Deeti; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Human embryonic stem cell line BJNhem20 pCAG-EGFP was generated using non-viral method (Fig. 1). The construct pCAG-EGFP was transfected using microporation procedure (C) 2015 The Authors. Published by Elsevier B.V.
Generation of OCIAD1 inducible overexpression human embryonic stem cell line: BJNhem20-OCIAD1-Tet-On

Shetty, Deeti K.; Shetty, Ronak; Inamdar, Maneesha S. (Elsevier Science Bv, 2016)

Human embryonic stem cell line BJNhem20-OCIAD1-Tet-On was generated using non-viral method. The constructs pCAG-Tet-On and pTRE-Tight vector driving OCIAD1 expression were transfected using microporation procedure. pCAG-Tet-On ...

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