Browsing by Author "Nagappa, Lakshmeesha K."

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Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase

Roy, Sourav; Karmakar, Tarak; Nagappa, Lakshmeesha K.; Rao, Vasudeva S. Prahlada; Balasubramanian, Sundaram; Balaram, Hemalatha (Wiley-Blackwell, 2016)

Hypoxanthine-guanine-xanthine phosphoribosyltransference (HGXPRT), a key enzyme in the purine salvage pathway of the malarial parasite, Plasmodium falciparum (Pf), catalyses the conversion of hypoxanthine, guanine, and ...
Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase

Roy, Sourav; Karmakar, Tarak; Rao, Vasudeva S. Prahlada; Nagappa, Lakshmeesha K.; Balasubramanian, Sundaram; Balaram, Hemalatha (Royal Society of Chemistry, 2015)

P. falciparum (Pf) hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) exhibits a unique mechanism of activation where the enzyme switches from a low activity (unactivated) to a high activity (activated) state ...

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