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Adaptation on rugged fitness landscapes

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dc.contributor.advisor Jain, Kavita
dc.contributor.author S., Sarada
dc.date.accessioned 2013-03-05T12:40:42Z
dc.date.available 2013-03-05T12:40:42Z
dc.date.issued 2012
dc.identifier.citation S., Sarada. 2012, Adaptation on rugged fitness landscapes, MS Engg thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/handle/10572/1289
dc.description.abstract We introduce some basic terms pertinent to our work and define the quantities that shall be used in later calculations. For the sake of Figure 1: Schematic representation of a rugged fitness landscape with many fitness peaks. Here A and C are local fitness peaks which are fitter than all their nearest neighbours while B is the fittest sequence and hence the global peak. The arrows represent the change in the sequence and fitness of the population. The population (shown by dot) climbs the fitness landscape during adaptation. simplicity, we work with binary sequences which can replicate and mutate. The replication rate of each sequence is given by its fitness and all possible sequences along with their associated fitness comprise the fitness landscape which encodes information about the environment. For example, when the carbon source of a E.coli population is composed of glucose there is only a single metabolism pathway and as expected, the fitness landscape is smooth with a single fitness peak but becomes rugged with many local peaks when the medium is a complex mixture of carbon sources which can be metabolised in multiple ways [3]. The ruggedness of the fitness landscape is determined by the correlations between fitness of the sequences: decreasing correlations produce increasing ruggedness with the completely correlated fitness landscape being smooth.
dc.language.iso English en_US
dc.publisher Jawaharlal Nehru Centre for Advanced Scientific Research en_US
dc.rights © 2012 JNCASR en_US
dc.subject Adaptation en_US
dc.subject Rugged fitness landscapes en_US
dc.title Adaptation on rugged fitness landscapes en_US
dc.type Thesis en_US
dc.type.qualificationlevel Master en_US
dc.type.qualificationname MS Engg en_US
dc.publisher.department Theoretical Sciences Unit (TSU) en_US


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