New Chemistry Unit (NCU): Recent submissions

Now showing items 261-277 of 277

Electronic grade and flexible semiconductor film employing oriented attachment of colloidal ligand-free PbS and PbSe nanocrystals at room temperature

Shanker, G. Shiva; Swarnkar, Abhishek; Chatterjee, Arindom; Chakraborty, S.; Phukan, Manabjyoti; Parveen, Naziya; Biswas, Kanishka; Nag, Angshuman (Royal Society of Chemistry, 2015)

Electronic grade semiconductor films have been obtained via the sintering of solution processed PbS and PbSe nanocrystals at room temperature. Prior attempts to achieve similar films required the sintering of nanocrystals ...
Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics

Uppu, Divakara S. S. M.; Manjunath, Goutham B.; Yarlagadda, Venkateswarlu; Kaviyil, Jyothi E.; Ravikumar, Raju; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta (Public Library Science, 2015)

Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (bla(NDM-1)) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old ...
Membrane Disruption and Enhanced Inhibition of Cell-Wall Biosynthesis: A Synergistic Approach to Tackle Vancomycin-Resistant Bacteria

Yarlagadda, Venkateswarlu; Samaddar, Sandip; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta (Wiley-V C H Verlag Gmbh, 2015)

Resistance to glycopeptide antibiotics, the drugs of choice for life-threatening bacterial infections, is on the rise. In order to counter the threat of glycopeptide-resistant bacteria, we report development of a new class ...
Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms

Hoque, Jiaul; Konai, Mohini M.; Samaddar, Sandip; Gonuguntala, Spandhana; Manjunath, Goutham B.; Ghosh, Chandradhish; Haldar, Jayanta (Royal Society of Chemistry, 2015)

Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the ...
Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection

Ghosh, Chandradhish; Manjunath, Goutham B.; Konai, Mohini M.; Uppu, Divakara S. S. M.; Hoque, Jiaul; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta (Public Library Science, 2015)

Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of ...
Lysine-Based Small Molecules That Disrupt Biofilms and Kill both Actively Growing Planktonic and Nondividing Stationary Phase Bacteria

Konai, Mohini M.; Haldar, Jayanta (American Chemical Society, 2015)

The emergence of bacterial resistance is a major threat to global health. Alongside this issue, formation of bacterial biofilms is another cause of concern because most antibiotics are ineffective against these recalcitrant ...
Structure-Activity Relationship of Amino Acid Tunable Lipidated Norspermidine Conjugates: Disrupting Biofilms with Potent Activity against Bacterial Persisters

Konai, Mohini M.; Adhikary, Utsarga; Samaddar, Sandip; Ghosh, Chandradhish; Haldar, Jayanta (American Chemical Society, 2015)

The emergence of bacterial resistance and biofilm associated infections has created a challenging situation in global health. In this present state of affairs where conventional antibiotics are falling short of being able ...
Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria

Yarlagadda, Venkateswarlu; Sarkar, Paramita; Manjunath, Goutham B.; Haldar, Jayanta (Pergamon-Elsevier Science Ltd, 2015)

Antibiotic-resistant superbugs such as vancomycin-resistant Enterococci (VRE) and Staphylococci have become a major global health hazard. To address this issue, we synthesized vancomycin aglycon dimers to systematically ...
Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'

Yarlagadda, Venkateswarlu; Konai, Mohini M.; Manjunath, Goutham B.; Ghosh, Chandradhish; Haldar, Jayanta (Japan Antibiotics Research Association, 2015)

Vancomycin, a glycopeptide antibiotic, has long been a drug of choice for life-threatening Gram-positive bacterial infections. Vancomycin confers its antibacterial activity by inhibiting bacterial cell wall biosynthesis. ...
Membrane Active Small Molecules Show Selective Broad Spectrum Antibacterial Activity with No Detectable Resistance and Eradicate Biofilms

Hoque, Jiaul; Konai, Mohini M.; Gonuguntla, Spandhana; Manjunath, Goutham B.; Samaddar, Sandip; Yarlagadda, Venkateswarlu; Haldar, Jayanta (American Chemical Society, 2015)

Treating bacterial biofilms With conventional antibiotics is limited due to ineffectiveness of the drugs and higher propensity to develop bacterial resistance. Development of new classes of antibacterial therapeutics with ...
Sequential One-Pot Synthesis of Tri- and Tetrasubstituted Thiophenes and Fluorescent Push Pull Thiophene Acrylates Involving (Het)aryl Dithioesters as Thiocarbonyl Precursors

Acharya, Anand; Parameshwarappa, G.; Saraiah, B.; Ila, H. (American Chemical Society, 2015)

An efficient, one-pot three component synthesis of highly functionalized tri- and tetrasubstituted thiophenes has been reported involving (het)aryl dithioesters as thiocarbonyl precursors. Thus, sequential base mediated ...
Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties

Avinash, M. B.; Raut, Devaraj; Mishra, Manish Kumar; Ramamurty, Upadrasta; Govindaraju, T. (Nature Publishing Group, 2015)

A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was utilized to synthesize molecular crystals of cyclic ...
Double zipper helical assembly of deoxyoligonucleotides: mutual templating and chiral imprinting to form hybrid DNA ensembles

Narayanaswamy, Nagarjun; Suresh, Gorle; Priyakumar, U. Deva; Govindaraju, T. (Royal Society of Chemistry, 2015)

Herein, the conventional and unconventional hydrogen bonding potential of adenine in APA for double zipper helical assembly of deoxyoligonucleotides is demonstrated under ambient conditions. The quantum mechanical calculations ...
Bioinspired Nanoarchitectonics of Naphthalene Diimide to Access 2D Sheets of Tunable Size, Shape, and Optoelectronic Properties

Pandeeswar, M.; Govindaraju, T. (Springer, 2015)

A bioinspired nanoarchitectonics design strategy is adapted to construct 2D sheets of promising n-type organic semiconductor naphthalene diimide (NDI) with tunable size, shape and optoelectronic properties. Modulation of ...
Crystallographic insight-guided nanoarchitectonics and conductivity modulation of an n-type organic semiconductor through peptide conjugation

Pandeeswar, M.; Khare, Harshavardhan; Ramakumar, Suryanarayanarao; Govindaraju, T. (Royal Society of Chemistry, 2015)

Crystallographic insight-guided nanoarchitectonics of peptide-conjugated naphthalene diimide (NDI) is described. In a bio-inspired approach, non-proteinogenic alpha-amino isobutyric acid (Aib)- and alanine (Ala)-derived ...
Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

Rajasekhar, K.; Chakrabarti, Malabika; Govindaraju, T. (Royal Society of Chemistry, 2015)

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one of the most devastating ailments among ...
Investigation of thermoelelectric properties of lead- free tin telluride and skutterudite

Banik, Ananya (Jawaharlal Nehru Centre for Advanced Scientific ResearchNew Chemistry Unit (NCU), 2015-10-23)

The rising global energy demand is causing a dramatic acceleration of social unrest. Impact of climate change on the environment due to combustion of nonrenewable energy sources is becoming increasingly alarming. Driven ...

Now showing items 261-277 of 277

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