Specification of the centromere location in most eukaryotes is not solely dependent on the DNA sequence. However, the non-genetic determinants of centromere identity are not clearly defined. While multiple mechanisms, ...
Janbon, Guilhem; Ormerod, Kate L.; Paulet, Damien; Byrnes, Edmond J., III; Yadav, Vikas; Chatterjee, Gautam; Mullapudi, Nandita; Hon, Chung-Chau; Billmyre, R. Blake; Brunel, Francois; Bahn, Yong-Sun; Chen, Weidong; Chen, Yuan; Chow, Eve W. L.; Coppee, Jean-Yves; Floyd-Averette, Anna; Gaillardin, Claude; Gerik, Kimberly J.; Goldberg, Jonathan; Gonzalez-Hilarion, Sara; Gujja, Sharvari; Hamlin, Joyce L.; Hsueh, Yen-Ping; Ianiri, Giuseppe; Jones, Steven; Kodira, Chinnappa D.; Kozubowski, Lukasz; Lam, Woei; Marra, Marco; Mesner, Larry D.; Mieczkowski, Piotr A.; Moyrand, Frederique; Nielsen, Kirsten; Proux, Caroline; Rossignol, Tristan; Schein, Jacqueline E.; Sun, Sheng; Wollschlaeger, Carolin; Wood, Ian A.; Zeng, Qiandong; Neuveglise, Cecile; Newlon, Carol S.; Perfect, John R.; Lodge, Jennifer K.; Idnurm, Alexander; Stajich, Jason E.; Kronstad, James W.; Sanyal, Kaustuv; Heitman, Joseph; Fraser, James A.; Cuomo, Christina A.; Dietrich, Fred S.(Public Library of Science, 2014)
Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ...
The continuous rise of antimicrobial resistance and the dearth of new antibiotics in the clinical pipeline raise an urgent call for the development of potent antimicrobial agents. Cationic chitosan derivatives, ...
As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ...
There is a significant need for developing compounds that kill Cryptococcus neoformans, the fungal pathogen that causes meningoencephalitis in immunocompromised individuals. Here, we report the mode of action of a designed ...
The centromere, on which kinetochore proteins assemble, ensures precise chromosome segregation. Centromeres are largely specified by the histone H3 variant CENP-A (also known as Cse4 in yeasts). Structurally, centromere ...
Hoque, Jiaul; Akkapeddi, Padma; Yadav, Vikas; Manjunath, Goutham B.; Uppu, Divakara S. S. M.; Konai, Mohini M.; Yarlagadda, Venkateswarlu; Sanyal, Kaustuv; Haldar, Jayanta(American Chemical Society, 2015)
Microbial attachment and subsequent colonization onto surfaces lead to the spread of deadly community-acquired and hospital-acquired (nosocomial) infections. Noncovalent immobilization of water insoluble and organo-soluble ...
Suryanarayanan, T. S.; Gopalan, Venkat; Sahal, Dinkar; Sanyal, Kaustuv(Indian Academy of Sciences, 2015)
Global conservation activities of animals and plants to protect endangered species are laudable. Similarly, various national and international bodies have recognized the value of preserving different types of microbes, the ...
High-fidelity chromosome segregation during cell division depends on a series of concerted interdependent interactions. Using a systems biology approach, we built a robust minimal computational model to comprehend mitotic ...
Varshney, Neha; Schaekel, Alida; Singha, Rima; Chakraborty, Tanmoy; van Wijlick, Lasse; Ernst, Joachim F.; Sanyal, Kaustuv(Genetics Society of America, 2015)
The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- ...