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Research Papers (Udaykumar Ranga)

Research Papers (Udaykumar Ranga)

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Temperature sensitivity of circadian clocks is conserved across Drosophila species melanogaster, malerkotliana and ananassae

Prabhakaran, Priya M.; Sheeba, Vasu (Informa Healthcare, 2014)

Light and temperature are the major environmental cycles that can synchronize circadian rhythms in a variety of organisms. Previously, we have shown that under light/dark cycles of various photoperiods, the Drosophila ...
Simulating natural light and temperature cycles in the laboratory reveals differential effects on activity/rest rhythm of four Drosophilids

Prabhakaran, Priya M.; Sheeba, Vasu (Springer, 2014)

Recent studies under semi-natural conditions have revealed various unique features of activity/rest rhythms in Drosophilids that differ from those under standard laboratory conditions. An additional afternoon peak (A-peak) ...
Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes

Dhanasekaran, Karthigeyan; Kumari, Sujata; Boopathi, Ramachandran; Shima, Hiroki; Swaminathan, Amrutha; Bachu, Mahesh; Ranga, Udaykumar; Igarashi, Kazuhiko; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

Positive coactivator 4 (PC4), a human transcriptional coactivator, is involved in diverse processes like chromatin organization and transcription regulation. It is hyperphosphorylated during mitosis, with unknown significance. ...
Toll-Like Receptor 9 Activation Rescues Impaired Antibody Response in Needle-free Intradermal DNA Vaccination

Arunachalam, Prabhu S.; Mishra, Ria; Badarinath, Krithika; Selvam, Deepak; Payeli, Sravan K.; Stout, Richard R.; Ranga, Udaykumar (Nature Publishing Group, 2016)

The delivery of plasmid DNA to the skin can target distinct subsets of dermal dendritic cells to confer a superior immune response. The needle-free immunization technology offers a reliable, safe and efficient means to ...
The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat

Aralaguppe, Shambhu Prasad G.; Sharma, Shilpee; Menon, Malini; Prasad, Vinayaka R.; Saravanan, Shanmugam; Murugavel, Kailapuri G.; Solomon, Suniti; Ranga, Udaykumar (Mary Ann Liebert, Inc, 2016)

Using several HIV-1 tat exon 1 amino acid sequences available from public databases and additional sequences derived from a southern Indian clinical cohort, we compared the profile of the signature amino acid residues (SAR) ...
Functional Incompatibility between the Generic NF-kappa B Motif and a Subtype-Specific Sp1III Element Drives the Formation of the HIV-1 Subtype C Viral Promoter

Verma, Anjali; Rajagopalan, Pavithra; Lotke, Rishikesh; Varghese, Rebu; Selvam, Deepak; Kundu, Tapas Kumar; Ranga, Udaykumar (American Society Microbiology, 2016)

Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-kappa B binding site found at ...
Genetic diversity and proviral DNA load in different neural compartments of HIV-1 subtype C infection

Mishra, Mamata; Varghese, Rebu K.; Verma, Anjali; Das, Sutanuka; Aguiar, Renato Santana; Tanuri, Amilcar; Mahadevan, Anita; Shankar, Susarla K.; Satishchandra, Parthasarathy; Ranga, Udaykumar (Springer, 2015)

In India, the low prevalence of HIV-associated dementia (HAD) in the Human immunodeficiency virus type 1 (HIV-1) subtype C infection is quite paradoxical given the high-rate of macrophage infiltration into the brain. Whether ...
Stealth anti-CD4 conjugated immunoliposomes with dual antiretroviral drugs - Modern Trojan horses to combat HIV

Ramana, Lakshmi Narashimhan; Sharma, Shilpee; Sethuraman, Swaminathan; Ranga, Udaykumar; Krishnan, Uma Maheswari (Elsevier Science Bv, 2015)

Highly active antiretroviral therapy (HAART) is the currently employed therapeutic intervention against AIDS where a drug combination is used to reduce the viral load. The present work envisages the development of a stealth ...

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