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Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness

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dc.contributor.author Lone, Shahnaz Rahman
dc.contributor.author Potdar, Sheetal
dc.contributor.author Srivastava, Manishi
dc.contributor.author Sharma, Vijay Kumar
dc.date.accessioned 2017-01-24T06:18:32Z
dc.date.available 2017-01-24T06:18:32Z
dc.date.issued 2016
dc.identifier.citation Lone, S. R.; Potdar, S.; Srivastava, M.; Sharma, V. K., Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness. Plos One 2016, 11 (3), 16 http://dx.doi.org/10.1371/journal.pone.0150596 en_US
dc.identifier.citation PLoS one en_US
dc.identifier.citation 11 en_US
dc.identifier.citation 3 en_US
dc.identifier.issn 1932-6203
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2078
dc.description Open Access en_US
dc.description.abstract Organisms quickly learn about their surroundings and display synaptic plasticity which is thought to be critical for their survival. For example, fruit flies Drosophila melanogaster exposed to highly enriched social environment are found to show increased synaptic connections and a corresponding increase in sleep. Here we asked if social environment comprising a pair of same-sex individuals could enhance sleep in the participating individuals. To study this, we maintained individuals of D. melanogaster in same-sex pairs for a period of 1 to 4 days, and after separation, monitored sleep of the previously socialized and solitary individuals under similar conditions. Males maintained in pairs for 3 or more days were found to sleep significantly more during daytime and showed a tendency to fall asleep sooner as compared to solitary controls (both measures together are henceforth referred to as "sleep-enhancement"). This sleep phenotype is not strain-specific as it is observed in males from three different "wild type" strains of D. melanogaster. Previous studies on social interaction mediated sleep-enhancement presumed 'waking experience' during the interaction to be the primary underlying cause; however, we found sleep-enhancement to occur without any significant increase in wakefulness. Furthermore, while sleep-enhancement due to group-wise social interaction requires Pigment Dispersing Factor (PDF) positive neurons; PDF positive and CRYPTOCHROME (CRY) positive circadian clock neurons and the core circadian clock genes are not required for sleep-enhancement to occur when males interact in pairs. Pair-wise social interaction mediated sleep-enhancement requires dopamine and olfactory signaling, while visual and gustatory signaling systems seem to be dispensable. These results suggest that socialization alone (without any change in wakefulness) is sufficient to cause sleep-enhancement in fruit fly D. melanogaster males, and that its neuronal control is context-specific. en_US
dc.description.uri http://dx.doi.org/10.1371/journal.pone.0150596 en_US
dc.language.iso English en_US
dc.publisher Public Library of Science en_US
dc.rights @ Public Library of Science en_US
dc.subject Memory Consolidation en_US
dc.subject Clock Neurons en_US
dc.subject Plasticity en_US
dc.subject Behavior en_US
dc.subject Brain en_US
dc.subject Melanogaster en_US
dc.subject Deprivation en_US
dc.subject Homeostasis en_US
dc.subject Arousal en_US
dc.subject Waking en_US
dc.title Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness en_US
dc.type Article en_US


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