DSpace Repository

A pharmacological overview of lamotrigine for the treatment of epilepsy

Show simple item record

dc.contributor.author Yasam, Venkata Ramesh
dc.contributor.author Jakki, Satya Lavanya
dc.contributor.author Senthil, V.
dc.contributor.author Eswaramoorthy, M.
dc.contributor.author Shanmuganathan, S.
dc.contributor.author Arjunan, K.
dc.contributor.author Nanjan, M. J.
dc.date.accessioned 2017-01-24T06:23:23Z
dc.date.available 2017-01-24T06:23:23Z
dc.date.issued 2016
dc.identifier.citation Venkata Ramesh Yasam, Satya Lavanya Jakki, V. Senthil, M. Eswaramoorthy, S. Shanmuganathan, K. Arjunan & MJ Nanjan (2016): A pharmacological overview of lamotrigine for the treatment of epilepsy, Expert Review of Clinical Pharmacology, DOI: 10.1080/17512433.2016.1254041 en_US
dc.identifier.citation Expert Review of Clinical Pharmacology en_US
dc.identifier.citation 9 en_US
dc.identifier.citation 12 en_US
dc.identifier.issn 1751-2433
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2129
dc.description Open Access (Accepted Manuscript) en_US
dc.description.abstract Introduction: Epilepsy is one of the most common neurological disorders, affecting about 2% of the population worldwide. Lamotrigine (LTG) is a second generation anti-epileptic drug (AED) with broad spectrum of activity, a favourable side-effect profile, simpler dosing than earlier drugs and efficacious in diverse epilepsy syndromes.Areas covered: The present review focuses on pharmacodynamics, pharmacokinetics, clinical efficacy, safety and tolerability of LTG and its effect on cognition, psychiatry, quality of life, women and pregnancy along with effect of enzyme inducing and enzyme inhibiting drugs over LTG and their effect on serum level fluctuations by collecting data from various studies over the years until 2016.Expert commentary: Results from various studies and clinical trials indicate that LTG possessed a favourable profile of anticonvulsant activity and good tolerability as a monotherapy/or add-on therapy in children and adult patients against several types of seizures and syndromes. It has wide clinical dose range with favourable pharmacokinetic properties making it an excellent therapeutic option in epilepsy. en_US
dc.description.uri 1751-2441 en_US
dc.description.uri http://dx.doi.org/10.1080/17512433.2016.1254041 en_US
dc.language.iso English en_US
dc.publisher Taylor & Francis Ltd en_US
dc.rights @Taylor & Francis Ltd, 2016 en_US
dc.subject Pharmacology & Pharmacy en_US
dc.subject Epilepsy en_US
dc.subject lamotrigine en_US
dc.subject pharmacokinetics en_US
dc.subject sodium channel blocker en_US
dc.subject women en_US
dc.subject Placebo-Controlled Trial en_US
dc.subject Add-On Drug en_US
dc.subject Randomized Controlled-Trial en_US
dc.subject Resistant Partial Seizures en_US
dc.subject Typical Absence Seizures en_US
dc.subject Newly-Diagnosed Epilepsy en_US
dc.subject Lennox-Gastaut-Syndrome en_US
dc.subject Tonic-Clonic Seizures en_US
dc.subject Double-Blind en_US
dc.subject Antiepileptic Drugs en_US
dc.title A pharmacological overview of lamotrigine for the treatment of epilepsy en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account