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Pigment dispersing factor-dependent and -independent Circadian locomotor behavioral rhythms

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dc.contributor.author Vasu, Sheeba
dc.contributor.author Sharma, V K
dc.contributor.author Gu, Huaiyu
dc.contributor.author Chou, Yu-Ting
dc.contributor.author O’Dowd, Diane K
dc.contributor.author Holmes, Todd C
dc.date.accessioned 2012-01-20T09:20:14Z
dc.date.available 2012-01-20T09:20:14Z
dc.date.issued 2008-01-02
dc.identifier 0270-6474 en_US
dc.identifier.citation The Journal of Neuroscience 28(1), 217-227 (2008) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/218
dc.description Restricted Access en_US
dc.description.abstract Circadian pacemaker circuits consist of ensembles of neurons, each expressing molecular oscillations, but how circuit-wide coordination of multiple oscillators regulates rhythmic physiological and behavioral outputs remains an open question. To investigate the relationship between the pattern of oscillator phase throughout the circadian pacemaker circuit and locomotor activity rhythms in Drosophila, we perturbed the electrical activity and pigment dispersing factor (PDF) levels of the lateral ventral neurons (LNv) and assayed their combinatorial effect on molecular oscillations in different parts of the circuit and on locomotor activity behavior. Altered electrical activity of PDF-expressing LNv causes initial behavioral arrhythmicity followed by gradual long-term emergence of two concurrent short-and long-period circadian behavioral activity bouts in similar to 60% of flies. Initial desynchrony of circuit-wide molecular oscillations is followed by the emergence of a novel pattern of period (PER) synchrony whereby two subgroups of dorsal neurons (DN1 and DN2) exhibit PER oscillation peaks coinciding with two activity bouts, whereas other neuronal subgroups exhibit a single PER peak coinciding with one of the two activity bouts. The emergence of this novel pattern of circuit-wide oscillator synchrony is not accompanied by concurrent change in the electrical activity of the LNv. In PDF-null flies, altered electrical activity of LNv drives a short-period circadian activity bout only, indicating that PDF-independent factors underlie the short-period circadian activity component and that the long-period circadian component is PDF-dependent. Thus, polyrhythmic behavioral patterns in electrically manipulated flies are regulated by circuit-wide coordination of molecular oscillations and electrical activity of LNv via PDF-dependent and -independent factors. en_US
dc.description.uri http://dx.doi.org/10.1523/JNEUROSCI.4087-07.2008 en_US
dc.language.iso en en_US
dc.publisher Society Neuroscience en_US
dc.rights © 2008 Society for Neuroscience en_US
dc.subject circadian en_US
dc.subject neural-network en_US
dc.subject Drosophila en_US
dc.subject synchronization en_US
dc.subject peptide modulation en_US
dc.subject voltage clamp en_US
dc.subject Cockroach Leucophaea-Maderae en_US
dc.subject Drosophila-Melanogaster en_US
dc.subject Pacemaker Neurons en_US
dc.subject Suprachiasmatic-Nucleus en_US
dc.subject Lateral Neurons en_US
dc.subject Clock Neurons en_US
dc.subject Functional-Analysis en_US
dc.subject Timeless Genes en_US
dc.subject Optic Lobes en_US
dc.subject Period en_US
dc.title Pigment dispersing factor-dependent and -independent Circadian locomotor behavioral rhythms en_US
dc.type Article en_US


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