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Circadian clocks of faster developing fruit fly populations also age faster

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dc.contributor.author Yadav, Pankaj
dc.contributor.author Sharma, Vijay Kumar
dc.date.accessioned 2017-02-16T11:37:42Z
dc.date.available 2017-02-16T11:37:42Z
dc.date.issued 2014
dc.identifier.citation Yadav, P; Sharma, VK, Circadian clocks of faster developing fruit fly populations also age faster. Biogerontology 2014, 15 (1) 33-45, http://dx.doi.org/10.1007/s10522-013-9467-y en_US
dc.identifier.citation Biogerontology en_US
dc.identifier.citation 15 en_US
dc.identifier.citation 1 en_US
dc.identifier.issn 1389-5729
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2318
dc.description Restricted Access en_US
dc.description.abstract Age-related changes in circadian rhythms have been studied in several model organisms including fruit flies Drosophila melanogaster. Although a general trend of period (tau) lengthening, reduction in rhythm strength and eventual arrhythmicity with increasing age has been reported, age-related changes in circadian rhythms have seldom been examined in the light of differences in the rate of ageing of the organism. We used four populations of fruit flies D. melanogaster which were selected to develop faster (as pre-adults) to ask if circadian clocks of these flies age faster than their controls. After 55 generations, the selected populations (FD) started developing similar to 29-h (similar to 12 %) faster than the controls (BD) while their circadian clocks exhibited tau similar to 0.5-h shorter than the controls. We assayed the activity/rest behaviour and adult lifespan of virgin males from the FD and BD populations under constant dark (DD) conditions. The results revealed that FD flies live significantly shorter, and markers of ageing of circadian rhythms set-in earlier in the FD flies compared to the BD controls, which suggests that circadian clocks of faster developing flies age faster than controls. These results can be taken to suggest that ageing of circadian clocks in fruit flies D. melanogaster is a function of its physiological rather than chronological age. en_US
dc.description.uri 1573-6768 en_US
dc.description.uri http://dx.doi.org/10.1007/s10522-013-9467-y en_US
dc.language.iso English en_US
dc.publisher Springer en_US
dc.rights @Springer, 2014 en_US
dc.subject Geriatrics & Gerontology en_US
dc.subject Circadian Rhythms en_US
dc.subject Faster Development en_US
dc.subject Ageing en_US
dc.subject Lifespan en_US
dc.subject Arrhythmicity en_US
dc.subject Period Lengthening en_US
dc.subject Bactrocera-Cucurbitae Diptera en_US
dc.subject Pre-Adult Development en_US
dc.subject Drosophila-Melanogaster en_US
dc.subject Life-Span en_US
dc.subject Sleep Duration en_US
dc.subject Correlated Responses en_US
dc.subject Artificial Selection en_US
dc.subject Developmental Period en_US
dc.subject Alzheimers-Disease en_US
dc.subject Locomotor-Activity en_US
dc.title Circadian clocks of faster developing fruit fly populations also age faster en_US
dc.type Article en_US


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