dc.contributor.author |
Yadav, Pankaj
|
|
dc.contributor.author |
Sharma, Vijay Kumar
|
|
dc.date.accessioned |
2017-02-16T11:37:42Z |
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dc.date.available |
2017-02-16T11:37:42Z |
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dc.date.issued |
2014 |
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dc.identifier.citation |
Yadav, P; Sharma, VK, Circadian clocks of faster developing fruit fly populations also age faster. Biogerontology 2014, 15 (1) 33-45, http://dx.doi.org/10.1007/s10522-013-9467-y |
en_US |
dc.identifier.citation |
Biogerontology |
en_US |
dc.identifier.citation |
15 |
en_US |
dc.identifier.citation |
1 |
en_US |
dc.identifier.issn |
1389-5729 |
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dc.identifier.uri |
https://libjncir.jncasr.ac.in/xmlui/10572/2318 |
|
dc.description |
Restricted Access |
en_US |
dc.description.abstract |
Age-related changes in circadian rhythms have been studied in several model organisms including fruit flies Drosophila melanogaster. Although a general trend of period (tau) lengthening, reduction in rhythm strength and eventual arrhythmicity with increasing age has been reported, age-related changes in circadian rhythms have seldom been examined in the light of differences in the rate of ageing of the organism. We used four populations of fruit flies D. melanogaster which were selected to develop faster (as pre-adults) to ask if circadian clocks of these flies age faster than their controls. After 55 generations, the selected populations (FD) started developing similar to 29-h (similar to 12 %) faster than the controls (BD) while their circadian clocks exhibited tau similar to 0.5-h shorter than the controls. We assayed the activity/rest behaviour and adult lifespan of virgin males from the FD and BD populations under constant dark (DD) conditions. The results revealed that FD flies live significantly shorter, and markers of ageing of circadian rhythms set-in earlier in the FD flies compared to the BD controls, which suggests that circadian clocks of faster developing flies age faster than controls. These results can be taken to suggest that ageing of circadian clocks in fruit flies D. melanogaster is a function of its physiological rather than chronological age. |
en_US |
dc.description.uri |
1573-6768 |
en_US |
dc.description.uri |
http://dx.doi.org/10.1007/s10522-013-9467-y |
en_US |
dc.language.iso |
English |
en_US |
dc.publisher |
Springer |
en_US |
dc.rights |
@Springer, 2014 |
en_US |
dc.subject |
Geriatrics & Gerontology |
en_US |
dc.subject |
Circadian Rhythms |
en_US |
dc.subject |
Faster Development |
en_US |
dc.subject |
Ageing |
en_US |
dc.subject |
Lifespan |
en_US |
dc.subject |
Arrhythmicity |
en_US |
dc.subject |
Period Lengthening |
en_US |
dc.subject |
Bactrocera-Cucurbitae Diptera |
en_US |
dc.subject |
Pre-Adult Development |
en_US |
dc.subject |
Drosophila-Melanogaster |
en_US |
dc.subject |
Life-Span |
en_US |
dc.subject |
Sleep Duration |
en_US |
dc.subject |
Correlated Responses |
en_US |
dc.subject |
Artificial Selection |
en_US |
dc.subject |
Developmental Period |
en_US |
dc.subject |
Alzheimers-Disease |
en_US |
dc.subject |
Locomotor-Activity |
en_US |
dc.title |
Circadian clocks of faster developing fruit fly populations also age faster |
en_US |
dc.type |
Article |
en_US |