dc.contributor.author |
Kumar, S. Vijay
|
|
dc.contributor.author |
Saraiah, B.
|
|
dc.contributor.author |
Parameshwarappa, G.
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|
dc.contributor.author |
Ila, H.
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|
dc.contributor.author |
Verma, Girijesh K.
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|
dc.date.accessioned |
2017-02-21T08:56:54Z |
|
dc.date.available |
2017-02-21T08:56:54Z |
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dc.date.issued |
2014 |
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dc.identifier.citation |
Kumar, SV; Saraiah, B; Parameshwarappa, G; Ila, H; Verma, GK, Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles. Journal of Organic Chemistry 2014, 79 (17) 7961-7978, http://dx.doi.org/10.1021/jo501114a |
en_US |
dc.identifier.citation |
Journal of Organic Chemistry |
en_US |
dc.identifier.citation |
79 |
en_US |
dc.identifier.citation |
17 |
en_US |
dc.identifier.uri |
https://libjncir.jncasr.ac.in/xmlui/10572/2490 |
|
dc.description |
Restricted Access |
en_US |
dc.description.abstract |
A novel, efficient route to substituted 1-N-(het)aryl/NH-2-(het)aryl-3-cyanoindoles and related pyrrolo-fused heterocycles such as thienopyrroles, pyrroloindoles, and pyrazolopyrroles has been reported. The overall protocol involves sequential cycloamination of readily available 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming processes, one base-mediated intermolecular and the other Cu-catalyzed intramolecular arylamination leading to N(1)-C(2) and N(1)-C(7a) bond formation, respectively, in a two-step one-pot procedure. |
en_US |
dc.description.uri |
http://dx.doi.org/10.1021/jo501114a |
en_US |
dc.language.iso |
English |
en_US |
dc.publisher |
American Chemical Society |
en_US |
dc.rights |
@American Chemical Society, 2014 |
en_US |
dc.subject |
Organic Chemistry |
en_US |
dc.subject |
H-Bond Functionalizations |
en_US |
dc.subject |
2,3-Disubstituted Indoles |
en_US |
dc.subject |
Efficient Synthesis |
en_US |
dc.subject |
Regioselective Synthesis |
en_US |
dc.subject |
Cross-Couplings |
en_US |
dc.subject |
Methylene Isocyanides |
en_US |
dc.subject |
2-Substituted Indoles |
en_US |
dc.subject |
Oxidative Cyclization |
en_US |
dc.subject |
Versatile Template |
en_US |
dc.subject |
Modular Synthesis |
en_US |
dc.title |
Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles |
en_US |
dc.type |
Article |
en_US |