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Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles

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dc.contributor.author Kumar, S. Vijay
dc.contributor.author Saraiah, B.
dc.contributor.author Parameshwarappa, G.
dc.contributor.author Ila, H.
dc.contributor.author Verma, Girijesh K.
dc.date.accessioned 2017-02-21T08:56:54Z
dc.date.available 2017-02-21T08:56:54Z
dc.date.issued 2014
dc.identifier.citation Kumar, SV; Saraiah, B; Parameshwarappa, G; Ila, H; Verma, GK, Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles. Journal of Organic Chemistry 2014, 79 (17) 7961-7978, http://dx.doi.org/10.1021/jo501114a en_US
dc.identifier.citation Journal of Organic Chemistry en_US
dc.identifier.citation 79 en_US
dc.identifier.citation 17 en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2490
dc.description Restricted Access en_US
dc.description.abstract A novel, efficient route to substituted 1-N-(het)aryl/NH-2-(het)aryl-3-cyanoindoles and related pyrrolo-fused heterocycles such as thienopyrroles, pyrroloindoles, and pyrazolopyrroles has been reported. The overall protocol involves sequential cycloamination of readily available 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming processes, one base-mediated intermolecular and the other Cu-catalyzed intramolecular arylamination leading to N(1)-C(2) and N(1)-C(7a) bond formation, respectively, in a two-step one-pot procedure. en_US
dc.description.uri http://dx.doi.org/10.1021/jo501114a en_US
dc.language.iso English en_US
dc.publisher American Chemical Society en_US
dc.rights @American Chemical Society, 2014 en_US
dc.subject Organic Chemistry en_US
dc.subject H-Bond Functionalizations en_US
dc.subject 2,3-Disubstituted Indoles en_US
dc.subject Efficient Synthesis en_US
dc.subject Regioselective Synthesis en_US
dc.subject Cross-Couplings en_US
dc.subject Methylene Isocyanides en_US
dc.subject 2-Substituted Indoles en_US
dc.subject Oxidative Cyclization en_US
dc.subject Versatile Template en_US
dc.subject Modular Synthesis en_US
dc.title Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles en_US
dc.type Article en_US


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