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Adaptive walks and distribution of beneficial fitness effects

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dc.contributor.author Seetharaman, Sarada
dc.contributor.author Jain, Kavita
dc.date.accessioned 2017-02-21T09:01:00Z
dc.date.available 2017-02-21T09:01:00Z
dc.date.issued 2014
dc.identifier.citation Seetharaman, S; Jain, K, ADAPTIVE WALKS AND DISTRIBUTION OF BENEFICIAL FITNESS EFFECTS. Evolution 2014, 68 (4) 965-975, http://dx.doi.org/10.1111/evo.12327 en_US
dc.identifier.citation Evolution en_US
dc.identifier.citation 68 en_US
dc.identifier.citation 4 en_US
dc.identifier.issn 0014-3820
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2531
dc.description Restricted Access en_US
dc.description.abstract We study the adaptation dynamics of a maladapted asexual population on rugged fitness landscapes with many local fitness peaks. The distribution of beneficial fitness effects is assumed to belong to one of the three extreme value domains, viz. Weibull, Gumbel, and Frechet. We work in the strong selection-weak mutation regime in which beneficial mutations fix sequentially, and the population performs an uphill walk on the fitness landscape until a local fitness peak is reached. A striking prediction of our analysis is that the fitness difference between successive steps follows a pattern of diminishing returns in the Weibull domain and accelerating returns in the Frechet domain, as the initial fitness of the population is increased. These trends are found to be robust with respect to fitness correlations. We believe that this result can be exploited in experiments to determine the extreme value domain of the distribution of beneficial fitness effects. Our work here differs significantly from the previous ones that assume the selection coefficient to be small. On taking large effect mutations into account, we find that the length of the walk shows different qualitative trends from those derived using small selection coefficient approximation. en_US
dc.description.uri 1558-5646 en_US
dc.description.uri http://dx.doi.org/10.1111/evo.12327 en_US
dc.language.iso English en_US
dc.publisher Wiley-Blackwell en_US
dc.rights @Wiley-Blackwell, 2014 en_US
dc.subject Ecology en_US
dc.subject Evolutionary Biology en_US
dc.subject Genetics & Heredity en_US
dc.subject Extreme Value Theory en_US
dc.subject Distribution Of Beneficial Fitnesses en_US
dc.subject Adaptive Walk en_US
dc.subject Strong Selection en_US
dc.subject RNA Virus en_US
dc.subject Pseudomonas-Fluorescens en_US
dc.subject Population-Genetics en_US
dc.subject Weak Mutation en_US
dc.subject DNA-Sequences en_US
dc.subject Adaptation en_US
dc.subject Evolution en_US
dc.subject Landscapes en_US
dc.subject Dynamics en_US
dc.title Adaptive walks and distribution of beneficial fitness effects en_US
dc.type Article en_US


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