There is a critical need for therapeutic agents that can target the amino-terminal domain (NTD) of androgen receptor (AR) for the treatment of castration-resistant prostate cancer (CRPC). Calmodulin (CaM) binds to the AR ...

A reaction-based strategy exploiting metal ion mediated oxidative C-O bond cleavage affords selective switch-on' near-infrared (NIR) emitting cyanine probe for Cu+ in aqueous media and live cells. Near-infrared fluorescence-ready ...

In mammalian spermiogenesis, haploid round spermatids undergo dramatic biochemical and morphological changes and transform into motile mature spermatozoa. A majority of the histones are replaced by transition proteins ...

This chapter provides a general introduction to phosphate monoester hydrolysis, the stereochemistry and mechanism of the reaction and the use of metal ions. It discusses several phosphatases with special emphasis on ...

Allostery refers to a phenomenon wherein binding of a ligand molecule at a site distinct from the active site brings about changes at the active site. Allostery may reveal itself as either inhibition or activation of the ...

Epilepsy is a neurological condition characterised by occurrence of recurrent seizures. It usually manifests with diverse clinical symptoms which, involve motor, sensory, cognitive and autonomic alterations with or without ...

A typical B-DNA molecule, which is a right handed helix, consists of two complementary polynucleotide chains that intertwine periodically to form a double helical structure. This provides topological features of the DNA ...

Macroautophagy (herein autophagy) is a mechanism in which cells sequester a part of cytoplasm within a double membrane structure called autophagosome and deliver it to the vacuole for degradation. The degradation products, ...

From Birth to Rebirth, every living cell progress through a defined set of well regulated events that constitute the “Cell Cycle”. This complex and well coordinated set of events with an accurate and precise control in ...

Genomic DNA in eukaryotic nucleus is compactly packaged to generate a highly ordered 3D hierarchical structure known as chromatin [1, 2]. Kornberg [5] proposed that chromatin is composed of a flexible chain of repeating ...