Effect of curcumin and Cu2+/Zn2+ ions on the fibrillar aggregates formed by the amyloid peptide and other peptides at the organic–aqueous interface

Sanghamitra, Nusrat J M; Varghese, Neenu; Rao, C N R

dc.contributor.author	Sanghamitra, Nusrat J M
dc.contributor.author	Varghese, Neenu
dc.contributor.author	Rao, C N R
dc.date.accessioned	2011-03-04T06:13:29Z
dc.date.available	2011-03-04T06:13:29Z
dc.date.issued	2010-08-20
dc.identifier	0009-2614	en_US
dc.identifier.citation	Chemical Physics Letters 496(1-3), 104–108 (2010)	en_US
dc.identifier.uri	https://libjncir.jncasr.ac.in/xmlui/10572/56
dc.description	Restricted access.	en_US
dc.description.abstract	Characteristic features of a perilous neuro-degenerative disease such as the Alzhiemer's disease is fibrillar plaque formation by the amyloid (A beta) peptide. We have modelled the formation and disintegration of fibrils by studying the aggregate structures formed by A beta structural motif diphenylalanine as well as insulin and bovine serum albumin at the organic aqueous interface. Even small concentrations of curcumin in the organic medium or Cu2+ and Zn2+ ions in the aqueous medium are found to break down the fibrillar structures. (C) 2010 Elsevier B.V. All rights reserved.	en_US
dc.description.uri	http://dx.doi.org/10.1016/j.cplett.2010.07.017	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier BV	en_US
dc.rights	© 2010 Elsevier BV	en_US
dc.subject	Beta Peptide	en_US
dc.subject	In-Vivo	en_US
dc.subject	A-Beta	en_US
dc.subject	Nanotubes	en_US
dc.subject	Diphenylalanine	en_US
dc.subject	Nanostructures	en_US
dc.subject	Biosynthesis	en_US
dc.subject	Plaques	en_US
dc.subject	Zinc	en_US
dc.title	Effect of curcumin and Cu2+/Zn2+ ions on the fibrillar aggregates formed by the amyloid peptide and other peptides at the organic–aqueous interface	en_US
dc.type	Article	en_US