• Mapping Post-translational Modifications of Mammalian Testicular Specific Histone Variant TH2B in Tetraploid and Haploid Germ Cells and Their Implications on the Dynamics of Nucleosome Structure 

  Pentakota, Satya Krishna; Sandhya, Sankaran; Sikarwar, Arun P.; Chandra, Nagasuma; Rao, M. R. S. (American Chemical Society, 2014)

  Histones regulate a variety of chromatin templated events by their post-translational modifications (PTMs). Although there are extensive reports on the PTMs of canonical histones, the information on the histone variants ...
• Genome wide chromatin occupancy of mrhl RNA and its role in gene regulation in mouse spermatogonial cells 

  Akhade, Vijay Suresh; Arun, Gayatri; Donakonda, Sainitin; Rao, M. R. S. (Landes Bioscience, 2014)

  Mrhl RNA is a nuclear lncRNA encoded in the mouse genome and negatively regulates Wnt signaling in spermatogonial cells through p68/Ddx5 RNA helicase. Mrhl RNA is present in the chromatin fraction of mouse spermatogonial ...
• A 16-Gene Signature Distinguishes Anaplastic Astrocytoma from Glioblastoma 

  Rao, Soumya Alige Mahabala; Srinivasan, Sujaya; Patric, Irene Rosita Pia; Hegde, Alangar Sathyaranjandas; Chandramouli, Bangalore Ashwathnarayanara; Arimappamagan, Arivazhagan; Santosh, Vani; Kondaiah, Paturu; Rao, M. R. S.; Somasundaram, Kumaravel (Public Library of Science, 2014)

  Anaplastic astrocytoma (AA; Grade III) and glioblastoma (GBM; Grade IV) are diffusely infiltrating tumors and are called malignant astrocytomas. The treatment regimen and prognosis are distinctly different between anaplastic ...
• Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells 

  Akhade, Vijay Suresh; Dighe, Shrinivas Nivrutti; Kataruka, Shubhangini; Rao, M. R. S. (Oxford University Press, 2016)

  Long non coding RNAs (lncRNAs) have emerged as important regulators of various biological processes. LncRNAs also behave as response elements or targets of signaling pathway(s) mediating cellular function. Wnt signaling ...
• Mapping of Post-translational Modifications of Transition Proteins, TP1 and TP2, and Identification of Protein Arginine Methyltransferase 4 and Lysine Methyltransferase 7 as Methyltransferase for TP2 

  Gupta, Nikhil; Madapura, M. Pradeepa; Bhat, U. Anayat; Rao, M. R. S. (American Society for Biochemistry and Molecular Biology Inc, 2015)

  Background: Transition proteins replace 90% of the nucleosomal histones during nucleo-histone to nucleo-protamine chromatin reconfiguration in mammalian spermiogenesis. Results: Major transition proteins, TP1 and TP2, ...
• Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1 

  Mishra, Laxmi N.; Gupta, Nikhil; Rao, M. R. S. (Elsevier Science Bv, 2015)

  In mammalian spermiogenesis, haploid round spermatids undergo dramatic biochemical and morphological changes and transform into motile mature spermatozoa. A majority of the histones are replaced by transition proteins ...
• Synthesis and structure of [C3N2H5][Cu(H2PO4)(2)Cl]·H2O with a chain structure: the first example of an organically templated copper (II) phosphate 

  Neeraj, S; Loiseau, T; Rao, C N R; Cheetham, A K (Elsevier Science BV, 2004-10)

  A new one-dimensional copper (II) phosphate, [C3N2H5][Cu(H2PO4)(2)Cl](H2O)-H-., I, with pseudo-10-membered channels along the b-axis formed by the hydrogen bonded chains, containing imidazolium ions has been synthesized ...
• δ-Aminolaevulate Synthetase Induction and Catalase Repression by Porphyrinogenic Drugs 

  Rao, M R S; Padmanaban, G (The Biochemical Society (Portland Press), 1971)
• An In Vitro, Short-Term Culture Method for Mammalian Haploid Round Spermatids Amenable for Molecular Manipulation 

  Dehnugara, Tushna; Dhar, Surbhi; Rao, M R S (Wiley-Blackwell, 2012-01)

  Extensive chromatin remodeling is a characteristic feature of mammalian spermiogenesis. To date, methods for the molecular manipulation of haploid spermatids are not available as there is a lack of a well-established culture ...
• Phosphorylation of Rat Spermatidal Protein TP2 by Sperm-specific Protein Kinase A and Modulation of Its Transport into the Haploid Nucleus 

  Ullas, Kolthur S; Rao, M R S (American Society for Biochemistry and Molecular Biology Inc, 2003-12-26)

  Transition protein 2 (TP2), which is expressed during stages 12-15 of mammalian spermiogenesis, has been shown to undergo phosphorylation immediately after its synthesis. We reported earlier that TP2 is phosphorylated in ...
• A K52Q substitution in the globular domain of histone H1t modulates its nucleosome binding properties 

  Ramesh, Sneha; Srinivas Bharath, M M; Chandra, Nagasuma R; Rao, M R S (Elsevier Science BV, 2006-10-30)

  A comparison of the globular domain sequences of the somatic H1d and testis-specific H1t revealed a single substitution of lysine 52 in H1d to glutamine 54 in H1t, which is one of the three crucial residues within the ...
• Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians 

  Radha, V; Vimaleswaran, K S; Babu, S; Deepa, R; Anjana, M; Ghosh, S; Majumder, P P; Rao, M R S; Mohan, V (Blackwell Publishing, 2007-04)

  Aims The aim of the study was to investigate the association of serum adiponectin levels with the Pro12Ala polymorphism of the peroxisome proliferator activated receptor-gamma (PPARG) gene in Asian Indians. Methods We ...
• Chromosome behaviour during meiosis 

  Rao, M R S; Ramachandrn, Lakshmi; Manjula, K (Indian Institute of Science, 1993-04)

  Pamng of homolopis chromosomes and genetlc recombmation are key features of n~cios~Ds.N .4 repair evcnts at the pachytene interval of mammalian germ cclls la very dlsunct and are ahen llnled to the genellc recombmanon ...
• ASCL1 (achaete-scute homolog 1 or achaete-scute complex homolog 1) 

  Ladha, Jayashree S; Rao, M R S (INIST-CNRS, 2007-07)
• Effects of U1 Nuclear RNA on Translation of Messenger RNA 

  Rao, M R S; Blackstone, Marilyn; Busch, Harris (American Chemical Society, 1977-06)

  U 1 nuclear RNA has the 5’-terminal sequence m32,2,7Gpp(p)AmUmACUUACCUGGCAGGGAGAUACCAGG- [Reddy, R., et al. (1974), J. Biol. Chem. 249, 6486; Ro-Choi, T. S., et al. (l974), Fed. Proc., Fed. Am. Soc. Exp. Biol. 33, ...
• Emerging concepts of chromatin remodeling in modulating genome functions 

  Dhar, Surbhi; Pradeepa, M M; Rao, M R S (National Academy Of Sciences India, 2007)

  The structural organization of eukaryotic chromatin plays an important role both in packaging DNA within the nucleus and in modulating various DNA transaction processes. In the last decade, we have seen rapid advances in ...
• The Relationship between Delta-Aminolaevulinate Synthetase Induction and the Concentrations of Cytochrome P-450 and Catalase in Rat Liver 

  Rao, M R S; Malathi, K; Padmanaban, G (The Biochemical Society, 1972)

  The porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction ...
• Novel Glioblastoma Markers with Diagnostic and Prognostic Value Identified through Transcriptome Analysis 

  Reddy, Sreekanth P; Britto, Ramona; Vinnakota, Katyayni; Aparna, Hebbar; Sreepathi, Hari Kishore; Thota, Balaram; Kumari, Arpana; Shilpa, B M; Vrinda, M; Umesh, Srikantha; Samuel, Cini; Shetty, Mitesh; Tandon, Ashwani; Pandey, Paritosh; Hegde, Sridevi; Hegde, A S; Balasubramaniam, Anandh; Chandramouli, B A; Santosh, Vani; Kondaiah, Paturu; Somasundaram, Kumaravel; Rao, M R S (American Association for Cancer Research, 2008-05-15)

  Purpose: Current methods of classification of astrocytoma based on histopathologic methods are often subjective and less accurate. Although patients with glioblastoma have grave prognosis, significant variability in patient ...
• PBEF1/NAmPRTase/Visfatin - A potential malignant astrocytoma/glioblastoma serum marker with prognostic value 

  Reddy, P Sreekanth; Umesh, Srikantha; Thota, Balaram; Tandon, Ashwani; Pandey, Paritosh; Hegde, A S; Balasubramaniam, Anandh; Chandramouli, B A; Santosh, Vani; Rao, M R S; Kondaiah, Paturu; Somasundaram, Kumaravel (Landes Bioscience, 2008-05)

  Malignant astrocytomas comprise anaplastic astrocytoma (AA; grade III) and Glioblastoma (GBM; grade IV). GBM is the most malignant with a median survival of 10-12 months in patients. Using cDNA microarray based expression ...
• The Human Mutator Gene Homolog MSHP and Its Association with Hereditary Nonpolyposis Colon Cancer 

  Fishel, Richard; Lescoe, Mary Kay; Rao, M R S; Copeland, Neal G; Jenkins, Nancy A; Garber, Judy; Kane, Michael; Kolodner, Richard (Cell Press, 1993-12)

  We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH2. Expression of hMSH2 in E. coli causes a dominant mutator phenotype, suggesting that hMSH2, like other divergent ...

View more