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Title: | Glycogen Synthase Kinase 3b as a Likely Target for the Action of Lithium on Circadian Clocks |
Authors: | Padiath, Quasar Saleem Paranjpe, Dhanashree Jain, Sanjeev Sharma, Vijay Kumar |
Keywords: | lithium Drosophila melanogaster circadian rhythms GSK 3 beta period elongation Bipolar Disorder Drosophila-Melanogaster Signaling Pathway Phase Advance Mechanism Wnt-7a Components Therapy Neurons Rhythms |
Issue Date: | 2004 |
Publisher: | Marcel Dekker Inc |
Citation: | Chronobiology International 21(1), 43-55 (2004) |
Abstract: | Although lithium is one of the most commonly used drugs in the prophylaxis and treatment or bipolar disorder, the mechanisms Underlying its therapeutic action are still unclear. Together with its mood-stabilizing effects, lithium is also known to influence the circadian clocks of several organisms ncluding man. Circadian rhythms are altered in patients with bipolar disorder, and it is believed that these rhythms may play an important role in disease mechanisms. It is therefore possible that some of the therapeutic actions of lithium may be related to its effect on circadian clocks. Identifying the targets for lithium's action on circadian clocks would therefore be important both for understanding the mechanisms of its therapeutic effect and also in further understanding disease mechanisms in bipolar disorders. Using Drosophila melanogaster as a model system, we show that long-term administration of lithium results in lengthening of the free-running period (tau) of circadian locomotor activity rhythm of flies in constant darkness (DD). This effect occurs at concentrations similar to the plasma levels of lithium used in the treatment of bipolar disorder. The lithium-treated flies also show reduced activity of one of the previously reported targets of lithium action, Glycogen Synthase Kinase 3beta (GSK 3beta). GSK 3beta has been shown to be involved in the regulation of circadian clocks as the down regulation of this protein results in an elongation of tau. The tau elongation resembles the effect seen with lithium administration in a number of organisms including man, and taken together with the earlier observations our results suggest that lithium inhibits the activity of GSK 3beta to produce its effect on circadian clocks. |
Description: | Restricted Access |
URI: | https://libjncir.jncasr.ac.in/xmlui/10572/224 |
Other Identifiers: | 0742-0528 |
Appears in Collections: | Research Articles (V. K. Sharma) |
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2004 Chronobiology International 21 43–55.pdf Restricted Access | 241.01 kB | Adobe PDF | View/Open Request a copy |
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