Please use this identifier to cite or link to this item:
Title: Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer
Authors: Rajasekhar, Kolla
Narayanaswamy, Nagarjun
Mishra, Piyush
Suresh, S. N.
Manjithaya, Ravi
Govindaraju, T.
Keywords: Chemistry
Relative Cell-Permeability
Issue Date: 2014
Publisher: Wiley-V C H Verlag Gmbh
Citation: Rajasekhar, K; Narayanaswamy, N; Mishra, P; Suresh, SN; Manjithaya, R; Govindaraju, T, Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer. Chempluschem 2014, 79 (1) 25-30,
Abstract: Cyclic peptoids are potential candidates for diverse biological activities. However, applications of cyclic peptoids are limited by the synthetic difficulties, conformational flexibility of large cyclic peptoids, and lack of secondary amide in the backbone. Herein, an elegant methodology for the synthesis of small and medium-size cyclic hybrid peptoids is developed. N-alpha-Alkyl and N-alpha-acyl substituents in N-(2-aminoethyl) glycine monomers enforce intra-and intermolecular cyclization to form stable six-and 12-membered cyclic products, respectively. NMR studies show inter-and intramolecular hydrogen bonding in six-and 12-membered cyclic peptoids, respectively. Screening of a cyclic peptoid library resulted in the identification of a potential candidate that enhanced autophagic degradation of cargo in a live cell model. Such upregulation of autophagy using small molecules is a promising approach for elimination of intracellular pathogens and neurodegenerative protein aggregates.
Description: Restricted Access
ISSN: 2192-6506
Appears in Collections:Research Papers (Govindaraju, T.)
Research Papers (Ravi Manjithaya)

Files in This Item:
File Description SizeFormat 
  Restricted Access
1.33 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.