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dc.contributor.advisorBalasubramanian, S.-
dc.contributor.authorKarmakar, Tarak-
dc.identifier.citationKarmakar, Tarak. 2016, Computational investigations on decarboxylase and phosphoribosyltransferase enzymes, Ph.D. thesis, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluruen_US
dc.descriptionOpen accessen_US
dc.description.abstractProteins are the most essential components of a living system. Their functions range from catalysis, transporting molecules and ions across cell membranes thereby maintaining electrochemical potentials in intra- and extracellular regions, signal transduction, and providing rigidity to cells and tissues. Proteins are constituted by amino acids that are covalently linked to each other to form a polypeptide chain. [1] The primary structure of a protein is the sequence of amino acids along the polymer. To a good extent, the sequence determines the structure of the protein. [2] The long polypeptide chain folds to form local structures, called the secondary structure of a protein. Among several secondary structures of a protein, -helix and -sheet are prominent. Other than these two, there are small 3/10-helices and random coils that connect the -helices and -sheets to produce a proper fold which is the tertiary structure of a protein. [3] In many cases, a number of such tertiary structures associate to form a quaternary structure. A quaternary structure can be formed by the assembling of either homomeric subunits or heteromeric subunits. [1, 3] A typical example of a quaternary structure is hemoglobin consisting of two 2 2-units of myoglobins.en_US
dc.publisherJawaharlal Nehru Centre for Advanced Scientific Researchen_US
dc.rights© 2016 JNCASRen_US
dc.titleComputational investigations on decarboxylase and phosphoribosyltransferase enzymesen_US
dc.publisher.departmentChemistry and Physics of Materials Unit (CPMU)en_US
Appears in Collections:Student Theses (CPMU)

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