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Title: On the Sequence of Reactions Leading to Cytochrome P-450 Synthesis-Effect of Drugs
Authors: Rajamanickam, Chellam
Rao, M R S
Padmanaban, Govindarajan
Keywords: 5-Aminolevulinate Synthetase-metabolism
Allylisopropylacetamide -pharmacology
Apoproteins - biosynthesis
Cycloheximide - pharmacology
Cytochrome P-450 Enzyme System - biosynthesis
Dactinomycin - pharmacology
Endoplasmic Reticulum - metabolism
Glycine - metabolism
Heme - biosynthesis
Iron - metabolism
Liver - drug effects
Liver - metabolism
Phenobarbital - pharmacology
Issue Date: 1975
Publisher: The American Society for Biochemistry and Molecular Biology Inc
Citation: Journal of Biological Chemistry 250(6), 2305-2310 (1975)
Abstract: The effect of phenobarbital on the rates of the synthesis of the protein and heme moieties of cytochrome P-450 has been studied. For this purpose, cytochrome P-450 has been partially purified as its P-420 derivative and the labeled amino acid incorporation into the protein has been studied after subjecting a partially purified preparation to sodium dodecyl sulfate gel electrophoresis. The incorporation studies into the protein species after sodium dodecyl sulfate gel electrophoresis reveal that the drug primarily accelerates the rate of apoprotein synthesis followed by an increase in the rate of heme synthesis. The messenger for apocytochrome P-450 appears to be fairly stable.
Description: Restricted Access
Other Identifiers: 0021-9258
Appears in Collections:Research Papers (M.R.S. Rao)

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