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dc.contributor.authorVimaleswaran, K S-
dc.contributor.authorRadha, V-
dc.contributor.authorAnjana, M-
dc.contributor.authorDeepa, R-
dc.contributor.authorGhosh, S-
dc.contributor.authorMajumder, P P-
dc.contributor.authorRao, M R S-
dc.contributor.authorMohan, V-
dc.date.accessioned2012-02-15T06:42:25Z-
dc.date.available2012-02-15T06:42:25Z-
dc.date.issued2006-06-
dc.identifier0307-0565en_US
dc.identifier.citationInternational Journal of Obesity 30(6), 884-891 (2006)en_US
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/10572/423-
dc.descriptionRestricted Accessen_US
dc.description.abstractObjective: To evaluate whether polymorphisms in the peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PPARGC1A) gene were related to body fat in Asian Indians. Methods: Three polymorphisms of PPARGC1A gene, the Thr394Thr, Gly482Ser and + A2962G, were genotyped on 82 type 2 diabetic and 82 normal glucose tolerant (NGT) subjects randomly chosen from the Chennai Urban Rural Epidemiology Study using PCR-RFLP, and the nature of the variants were confirmed using direct sequencing. Linkage disequilibrium (LD) was estimated from the estimates of haplotypic frequencies using an expectation-maximization algorithm. Visceral, subcutaneous and total abdominal fat were measured using computed tomography, whereas dual X-ray absorptiometry was used to measure central abdominal and total body fat. Results: None of the three polymorphisms studied were in LD. The genotype (0.59 vs 0.32, P = 0.001) and allele (0.30 vs 0.17, P = 0.007) frequencies of Thr394Thr polymorphism were significantly higher in type 2 diabetic subjects compared to those in NGT subjects. The odds ratio for diabetes (adjusted for age, sex and body mass index) for the susceptible genotype, XA (GA + AA) of Thr394Thr polymorphism, was 2.53 (95% confidence intervals: 1.30-5.04, P = 0.009). Visceral and subcutaneous fat were significantly higher in NGT subjects with XA genotype of the Thr394Thr polymorphism compared to those with GG genotype (visceral fat: XA 148.2 +/- 46.9 vs GG 106.5 +/- 51.9 cm(2), P = 0.001; subcutaneous fat: XA 271.8 +/- 167.1 vs GG 181.5 +/- 78.5 cm(2), P = 0.001). Abdominal (XA 4521.9 +/- 1749.6 vs GG 3445.2 +/- 1443.4 g, P = 0.004), central abdominal (XA 1689.0 +/- 524.0 vs GG 1228.5 +/- 438.7 g, P < 0.0001) and non-abdominal fat ( XA 18763.8 +/- 8789.4 vs GG 13160.4 +/- 4255.3 g, P < 0.0001) were also significantly higher in the NGT subjects with XA genotype compared to those with GG genotype. The Gly482Ser and + A2962G polymorphisms were not associated with any of the body fat measures. Conclusion: Among Asian Indians, the Thr394Thr (G -> A) polymorphism is associated with increased total, visceral and subcutaneous body fat.en_US
dc.description.urihttp://dx.doi.org/10.1038/sj.ijo.0803228en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rights© 2006 Nature Publishing Groupen_US
dc.subjectPPARGC1Aen_US
dc.subjectgeneticsen_US
dc.subjecttotal body faten_US
dc.subjectcomputed tomographyen_US
dc.subjectdual X-ray absorptiometryen_US
dc.subjectAsian Indiansen_US
dc.subjectAbdominal Visceral Faten_US
dc.subjectChennai Urban-Populationen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectDiabetes- Mellitusen_US
dc.subjectQuebec Familyen_US
dc.subjectDiseaseen_US
dc.subjectObesityen_US
dc.subjectCoactivatoren_US
dc.subjectPrevalenceen_US
dc.titleEffect of polymorphisms in the PPARGC1A gene on body fat in Asian Indiansen_US
dc.typeArticleen_US
Appears in Collections:Research Papers (M.R.S. Rao)

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