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Title: Effect of Hexachlorobenzene on Haem Synthesis
Authors: Rajamanickam, Chellam
Amrutavalli, J
Rao, M R S
Padmanaban, G
Keywords: 5-Aminolevulinate Synthetase - metabolism
Amino Acids - metabolism
Benzene Derivatives
Cytochrome P-450 Enzyme System - metabolism
Enzyme Induction
Heme - biosynthesis
Liver - drug effects
Liver - drug effects
Organ Size
Porphobilinogen - metabolism
Porphyrias - chemically induced
Porphyrins - metabolism
Issue Date: 1972
Publisher: The Biochemical Society (Portland Press)
Citation: Biochemical Journal 129(2), 381-7 (1972)
Abstract: Several drugs are known to induce the liver microsomal mixed-function oxidase system when administered in vivo or even in vitro in cell culture. A sequence of events has been suggested in which the drug is visualized to induce delta-aminolaevulinate synthetase, the first and rate-limiting enzyme of the haem-biosynthetic pathway, which is followed by enhanced haem synthesis and cytochrome P-450 content, facilitating the increase in the drug-metabolizing activity of the liver microsomal fraction. The present studies show that the fungicide hexachlorobenzene, when administered to female rats, can lead to enhanced amounts and rate of synthesis of cytochrome P-450 under conditions when the rate of total haem synthesis has not appreciably altered. The subsequent increase in the rate of total haem synthesis as well as the initial increase in amounts of cytochrome P-450 are brought about under conditions when delta-aminolaevulinate synthetase activity remains constant. However, manifestation of porphyria due to prolonged drug administration is accompanied by a twofold increase in delta-aminolaevulinate synthetase activity. The increase in enzyme activity appears to be due to a decreased degradation rate of the enzyme.
Description: Restricted Access
Other Identifiers: 0264-6021
Appears in Collections:Research Papers (M.R.S. Rao)

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