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Please use this identifier to cite or link to this item: https://libjncir.jncasr.ac.in/xmlui/handle/10572/581
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dc.contributor.authorRao, M R S-
dc.contributor.authorMalathi, K-
dc.contributor.authorPadmanaban, G-
dc.date.accessioned2012-03-07T11:16:23Z-
dc.date.available2012-03-07T11:16:23Z-
dc.date.issued1972-
dc.identifier0264-6021en_US
dc.identifier.citationBiochemical Journal 127(3), 553-559 (1972)en_US
dc.identifier.urihttps://libjncir.jncasr.ac.in/xmlui/10572/581-
dc.descriptionRestricted Accessen_US
dc.description.abstractThe porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction of δ-aminolaevulinate synthetase and the consequent overproduction of haem. The allylisopropylacetamide-mediated breakdown of cytochrome P-450 is a rapid event and has a reciprocal relationship to the pattern of δ-aminolaevulinate synthetase induction. Breakdown of cytochrome P-450 appears to be one of the conditions leading to the `derepression' of δ-aminolaevulinate synthetase.en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1178697/en_US
dc.language.isoenen_US
dc.publisherThe Biochemical Societyen_US
dc.rights© 1972 The Biochemical Societyen_US
dc.subject5-Aminolevulinate Synthetase - biosynthesisen_US
dc.subjectAmides - pharmacologyen_US
dc.subjectAnimalsen_US
dc.subjectBilirubin - pharmacologyen_US
dc.subjectCatalase - biosynthesisen_US
dc.subjectCycloheximide - pharmacologyen_US
dc.subjectCytochrome P-450 Enzyme System - biosynthesisen_US
dc.subjectEnzyme Inductionen_US
dc.subjectFemaleen_US
dc.subjectGlucose - pharmacologyen_US
dc.subjectHalf-Lifeen_US
dc.subjectHeme - pharmacologyen_US
dc.subjectLiver - enzymologyen_US
dc.subjectMicrosomesen_US
dc.subjectLiver - metabolismen_US
dc.subjectPhenobarbital - pharmacologyen_US
dc.subjectPorphyrins - metabolismen_US
dc.subjectProadifen - pharmacologyen_US
dc.subjectRatsen_US
dc.titleThe Relationship between Delta-Aminolaevulinate Synthetase Induction and the Concentrations of Cytochrome P-450 and Catalase in Rat Liveren_US
dc.typeArticleen_US
Appears in Collections:Research Papers (M.R.S. Rao)

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