Functional cooperativity of tumor suppressor p53 and transcriptional coactivator PC4: transcription to repair

Abstract

In a complex but highly coordinated eukaryotic system, transcriptional regulation and the regulation of cellular protein functions by covalent modifications are critically important to maintain the cellular homeostasis. Under stress or pathological conditions different general transcription factors (activators/repressors) and coactivators develop the initial line of responses. The cross talk among the basal transcription machinery and regulatory proteins therefore, is essential to maintain the proper cellular physiology. However, the posttranslational modifications of histones as well as nonhistone proteins also contribute significantly to many cellular phenomena.