Abstract:
In a complex but highly coordinated eukaryotic system, transcriptional regulation
and the regulation of cellular protein functions by covalent modifications are critically
important to maintain the cellular homeostasis. Under stress or pathological conditions
different general transcription factors (activators/repressors) and coactivators develop the
initial line of responses. The cross talk among the basal transcription machinery and
regulatory proteins therefore, is essential to maintain the proper cellular physiology.
However, the posttranslational modifications of histones as well as nonhistone proteins
also contribute significantly to many cellular phenomena.
