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Title: An 18 mer sequence in a rat 1.3 kbp EcoRI repeat detects genetic polymorphism in humans
Authors: Ramachandra, Lakshmi
Devi, A Radha Rama
Rao, M R S
Keywords: Human DNA
Hypervariable Minisatellites
Issue Date: 10-Oct-1993
Publisher: Current Science Association
Citation: Current Science 65(7), 569-571 (1993)
Abstract: DNA fingerprinting involves the typing of an individual's DNA content to produce somatically stable, individual-specific DNA fingerprints. This technique often uses hypervariable minisatellite (HVMS) sequences as the fingerprinting probe and has found extensive use in several disciplines. Recently, we sequenced a 1.3 kbp EcoRI repetitive DNA fragment, shown to harbour the meiotic DNA repair site(s) of rat pachytene spermatocytes. This 1.3 kbp clone contained four sequences sharing high homology to the various HVMS sequences reported in the literature. Here we show that one of the sequences can indeed detect polymorphism in human individuals and can be used for DNA fingerprinting.
Description: Open Access.
Other Identifiers: 0011-3891
Appears in Collections:Research Papers (M.R.S. Rao)

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