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Browsing by Author "Balaram, Hemalatha"

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Adenylosuccinate lyase and metabolic fate of fumarate in the intraerythrocytic stages of plasmodium falciparum

Bulusu, Vinay (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2010)

This chapter gives an introduction on Plasmodium falciparum life cycle and its metabolism. Studying P. falciparum metabolism will not only lead to novel biochemical targets for chemotherapeutic intervention but also ...
Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila

Srinivasan, Bharath; Forouhar, Farhad; Shukla, Arpit; Sampangi, Chethana; Kulkarni, Sonia; Abashidze, Mariam; Seetharaman, Jayaraman; Lew, Scott; Mao, Lei; Acton, Thomas B.; Xiao, Rong; Everett, John K.; Montelione, Gaetano T.; Tong, Liang; Balaram, Hemalatha (Wiley-Blackwell, 2014)

Cytosolic nucleotidase II (cN-II) from Legionellapneumophila (Lp) catalyzes the hydrolysis of GMP and dGMP displaying sigmoidal curves, whereas catalysis of IMP hydrolysis displayed a biphasic curve in the initial rate ...
Biochemical and physiological investigations on adenosine monophosphate deaminase and haloacid dehalogenase superfamily members from plasmodium spp

K.N., Lakshmeesha (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2019)

The current study focuses on the preliminary characterization of a purine nucleotide cycle enzyme, AMP deaminase (AMPD hereafter) and members of the Haloacid Dehalogenase superfamily (HADSF) from Plasmodium falciparum and ...
Biochemical characterization of plasmodium falciparum glutamine amidotransferase and adenosine triphosphate pyrophosphatase : domains of GMP synthetase

Thota, Lakshmi Prasoona (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2012)

Allostery refers to a phenomenon wherein binding of a ligand molecule at a site distinct from the active site brings about changes at the active site. Allostery may reveal itself as either inhibition or activation of the ...
Biochemical studies on inosine 5'-monophosphate dehydrogenase from the mesophilic protozoan plasmodium falciparum and hyperthermophilic archaeon methanocaldococcus jannaschii

Prasoona, Thota Lakshmi (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2019)

Abstract not available
Catalytic mechanism and stereospecificity in class-I fumarate hydratase and L-tartrate dehydratase, and structural characterization of an archaeal IMP dehydrogenase

Bellur, Asutosh (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2022-04)

Abstract not available
Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue96 in the Plasmodial Enzyme

Pareek, Vidhi; Samanta, Moumita; Joshi, Niranjan V.; Balaram, Hemalatha; Murthy, Mathur R. N.; Balaram, Padmanabhan (Wiley-V C H Verlag Gmbh, 2016)

Despite extensive research into triosephosphate isomerases (TIMs), there exists a gap in understanding of the remarkable conjunction between catalytic loop-6 (residues 166-176) movement and the conformational flip of Glu165 ...
Exquisite Modulation of the Active Site of Methanocaldococcus jannaschii Adenylosuccinate Synthetase in Forward Reaction Complexes

Karnawat, Vishakha; Mehrotra, Sonali; Balaram, Hemalatha; Puranik, Mrinalini (American Chemical Society, 2016)

In enzymes that conduct complex reactions involving several substrates and chemical transformations, the active Site must reorganize at each step to complement the transition state of that chemical step. Adenylosuccinate ...
Generation of knockout/knockdown of aspartate aminotransferase and malate quinone oxidoreductase in plasmodium

Suryavanshi, Arpitha (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2015)

Plasmodium, a protozoan parasite is the causative agent of malaria. In 1880, Charles Louis Alphonse Laveran, a French army surgeon was the first to observe Plasmodium parasites in the blood of patients who suffered from ...
A Histidine Aspartate Ionic Lock Gates the Iron Passage in Miniferritins from Mycobacterium smegmatis

Williams, Sunanda Margrett; Chandran, Anu V.; Vijayabaskar, Mahalingam S.; Roy, Sourav; Balaram, Hemalatha; Vishveshwara, Saraswathi; Vijayan, Mamannamana; Chatterji, Dipankar (American Society Biochemistry Molecular Biology Inc, 2014)

Background: DNA-binding protein from starved cells (Dps) are nano-compartments that can oxidize and store iron rendering protection from free radicals. Results: A histidine-aspartate ionic cluster in mycobaterial Dps2 ...
IMP specific 5' -nucleotidase 1: in vitro characterization and attempts at conditional knockdown in plasmodium falciparum

Varma, Neelakshi (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2017)

Plasmodium falciparum is one of the five species of Plasmodium that infect humans to cause malaria, which is one of the leading causes of death in low-income countries. It possesses a highlyspecialized metabolism which ...
Investigations on the plasmodium falciparum, human and chimeric hypoxanthine guanine phosphoribosyltransferases

Subbayya, Sujay I.N. (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2002)

Abstract not available
Kinetic mechanism, ammonia channeling and domain cross-talk in Plasmodium falciparum GMP synthetase : an amido- transferase

Yousuf, Bhat Javaid (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2010)

Glutamine amidotransferases (Gln-ATs) or transamidases, are the enzymes catalyzing amination of a wide variety of metabolites, like amino acids, purines, pyrimidines, amino sugars, coenzymes and antibiotics, that sometimes ...
Mechanistic underpinnings of substrate recognition, catalysis and allostery in GMP synthetases

Shivakumaraswamy, Santosh (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2019)

This chapter introduces the reader to the glutamine amidotransferase (GAT) family of enzymes. A brief overview of the reaction catalyzed by these enzymes and the highlights of functioning are presented. This is followed ...
Metabolic significance of fumarate in plasmodium falciparum and biochemical and structural characterization of class I fumarate hydratase from plasmodium falciparum and methanocaldococcus jannaschii

Vijay, J. (Jawaharlal Nehru Centre for Advanced Scientific ResearchMBGU, 2017)

Energy metabolism in Plasmodium falciparum asexual stages is unique with respect to the set of pathways used to achieve the objective function of biomass production. ATP demand of the parasite is almost completely met ...
Methanocaldococcus jannaschii GMP synthetase : investigations on aspects of catalysis and the role of an unusual posttranslational modification in structure and function

Kumar, Sanjeev (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2014)

"This chapter describes key features of glutamine amidotransferases (GATs). Glutamine amidotransferases are the enzymes that transfer ammonia derived from glutamine to various acceptor substrates. Apart from having ...
Preliminary studies on plasmodium falciparum adenosine 5'monophosphate deaminase

K.N., Lakshmeesha (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2014)

"The current study focuses on the preliminary characterisation of a purine nucleotide cycle enzyme, AMP deaminase (AMPD hereafter) from Plasmodium falciparum. Purine nucleotide cycle performs inter-conversion of IMP and ...
Protein structure and dynamics: Studies on the plasmodial proteins - triosephosphate isomerase (TIM) and hypoxanthine guanine phosphoribosyltransferase (HGPRT) and plasmepsin II

Pattaniak, Priyaranjan (Jawaharlal Nehru Centre for Advanced Scientific ResearchMolecular Biology and Genetics Unit (MBGU), 2003)

Abstract not available
Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase

Roy, Sourav; Karmakar, Tarak; Nagappa, Lakshmeesha K.; Rao, Vasudeva S. Prahlada; Balasubramanian, Sundaram; Balaram, Hemalatha (Wiley-Blackwell, 2016)

Hypoxanthine-guanine-xanthine phosphoribosyltransference (HGXPRT), a key enzyme in the purine salvage pathway of the malarial parasite, Plasmodium falciparum (Pf), catalyses the conversion of hypoxanthine, guanine, and ...
Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase

Roy, Sourav; Karmakar, Tarak; Rao, Vasudeva S. Prahlada; Nagappa, Lakshmeesha K.; Balasubramanian, Sundaram; Balaram, Hemalatha (Royal Society of Chemistry, 2015)

P. falciparum (Pf) hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) exhibits a unique mechanism of activation where the enzyme switches from a low activity (unactivated) to a high activity (activated) state ...

Now showing items 1-20 of 31

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