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A Comparative Study of the Early Effects of Phenobarbital and 3-Methylcholanthrene on the Synthesis and Transport of Ribonucleic Acid in Rat Liver

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dc.contributor.author Kumar, Ashwani
dc.contributor.author Rao, M R S
dc.contributor.author Padmanaban, Govindarajan
dc.date.accessioned 2011-05-20T06:48:52Z
dc.date.available 2011-05-20T06:48:52Z
dc.date.issued 1980
dc.identifier.citation Biochemical Journal 186(1), 81–87 (1980) en_US
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/119
dc.description Restricted access en_US
dc.description.abstract At 2-3 h after phenobaribtal administration, the drug has no effect on nucleoplasmic RNA synthesis and decreases nucleolar RNA synthesis. However, at this time there is an increase in the labelling of cytoplasmic poly(A)-containing RNA, even though there is decreased labelling of total polyribosomal RNA. The decrease in labelling of nucleolar and total polyribosomal RNA owing to phenobarbital is a transient phenomenon. Under similar conditions, 3-methylcholanthrene has no effect on nucleolar RNA synthesis, but leads to an increase in synthesis of nucleoplasmic and cytoplasmic poly(A)-containing RNA. Cytosol isolated from phenobarbital-treated, but not from 3-methyl-cholanthrene-treated, animals facilitates an enhanced transport of RNA from nuclei. At the time points investigated, 3-methylcholanthrene or its metabolite shows a 10-15-fold higher concentration in the chromatin than that of phenobarbital or its metabolite. It is suggested that the primary effect of phenobarbital is at the cytoplasmic level, promoting the transport of RNA from the nuclei, which can act as a trigger for enhanced transcription at later periods. 3-Methylcholanthrene or its metabolite directly binds to the chromatin and evokes a selective transcriptional response. en_US
dc.description.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1161505/ en_US
dc.language.iso en en_US
dc.publisher The Biochemical Society en_US
dc.rights © 1980 The Biochemical Society en_US
dc.subject Phenobarbital en_US
dc.subject 3-Methylcholanthrene en_US
dc.subject Synthesis en_US
dc.subject Transport en_US
dc.subject Ribonucleic Acid en_US
dc.subject Rat Liver en_US
dc.title A Comparative Study of the Early Effects of Phenobarbital and 3-Methylcholanthrene on the Synthesis and Transport of Ribonucleic Acid in Rat Liver en_US
dc.type Article en_US


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