The alarming growth of antibiotic resistant superbugs such as vancomycin-resistant Enterococci and Staphylococci has become a major global health hazard. To address this issue, we report the development of lipophilic ...
Hoque, Jiaul; Gonuguntla, Spandhana; Yarlagadda, Venkateswarlu; Aswal, Vinod K.; Haldar, Jayanta(Royal Society of Chemistry, 2014)
This study provides an insight into the micellar aggregation properties in aqueous solutions of various gemini surfactants bearing one or more amide groups at the side chains and/or in the spacer by conductivity and small ...
Konai, Mohini M.; Ghosh, Chandradhish; Yarlagadda, Venkateswarlu; Samaddar, Sandip; Haldar, Jayanta(American Chemical Society, 2014)
Natural and synthetic membrane active antibacterial agents offer hope as potential solutions to the problem of bacterial resistance as the membrane-active nature imparts low propensity for the development of resistance. ...
Uppu, D. S. S. M.; Konai, M. M.; Baul, U.; Singh, P.; Siersma, T. K.; Samaddar, S.; Vemparala, S.; Hamoen, L. W.; Narayana, Chandrabhas; Haldar, Jayanta(Royal Society of Chemistry, 2016)
Biomimetic antibacterial polymers, the functional mimics of antimicrobial peptides (AMPs), targeting the bacterial cell membrane have been developed to combat the problem of antibiotic resistance. Amphiphilicity, a balance ...
Yarlagadda, Venkateswarlu; Sarkar, Paramita; Samaddar, Sandip; Haldar, Jayanta(Wiley-V C H Verlag Gmbh, 2016)
Vancomycin, the drug of last resort for Gram-positive bacterial infections, has also been rendered ineffective by the emergence of resistance in such bacteria. To combat the threat of vancomycin-resistant bacteria (VRB), ...
Hoque, Jiaul; Konai, Mohini M.; Sequeira, Shanola S.; Samaddar, Sandip; Haldar, Jayanta(American Chemical Society, 2016)
More than 80% of the bacterial infections are associated with biofilm formation. To combat infections, amphiphilic small molecules have been developed as promising antibiofilm agents. However, cytotoxicity of such molecules ...
Hoque, Jiaul; Akkapeddi, Padma; Ghosh, Chandradhish; Uppu, Divakara S. S. M.; Haldar, Jayanta(American Chemical Society, 2016)
Bacterial colonization and subsequent formation of biofilms onto surfaces of medical devices and implants is a major source of nosocomial infections. Most antibacterial coatings to combat infections are either metal-based ...
The emergence of drug resistance along with a declining pipeline of clinically useful antibiotics has made it vital to develop more effective antimicrobial therapeutics, particularly against difficult-to-treat Gram-negative ...
Staphylococcus aureus is a facultative intracellular pathogen and there are limited options for the treatment of severe intracellular bacterial infections. The membrane-active glycopeptide antibiotic Van-QC(8) is a permanent ...
Ghosh, Chandradhish; Manjunath, Goutham B.; Konai, Mohini M.; Uppu, Divakara S. S. M.; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Ravikumar, Raju; Haldar, Jayanta(American Chemical Society, 2016)
Infections caused by drug-resistant Gramnegative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens, against which ...
Ghosh, Chandradhish; Konai, Mohini Mohan; Sarkar, Paramita; Samaddar, Sandip; Haldar, Jayanta(Wiley-V C H Verlag Gmbh, 2016)
In the global effort to thwart antimicrobial resistance, lipopeptides are an important class of antimicrobial agents, especially against Gram-negative infections. In an attempt to circumvent their synthetic complexities, ...
Uppu, D. S. S. M.; Bhowmik, M.; Samaddar, S.; Haldar, Jayanta(Royal Society of Chemistry, 2016)
Membrane-active agents represent a promising alternative to overcome antibiotic resistance. Here, we report cationic-amphiphilic polymers with variations in the side chain architecture such as cyclization, isomerization ...
Uppu, Divakara S. S. M.; Haldar, Jayanta(American Chemical Society, 2016)
Synthetic polymers incorporating the cationic charge and hydrophobicity to mimic the function of antimicrobial peptides (AMPs) have been developed. These cationic-amphiphilic polymers bind to bacterial membranes that ...
The continuous rise of antimicrobial resistance and the dearth of new antibiotics in the clinical pipeline raise an urgent call for the development of potent antimicrobial agents. Cationic chitosan derivatives, ...
Uppu, Divakara S. S. M.; Manjunath, Goutham B.; Yarlagadda, Venkateswarlu; Kaviyil, Jyothi E.; Ravikumar, Raju; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta(Public Library Science, 2015)
Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (bla(NDM-1)) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old ...
Yarlagadda, Venkateswarlu; Samaddar, Sandip; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta(Wiley-V C H Verlag Gmbh, 2015)
Resistance to glycopeptide antibiotics, the drugs of choice for life-threatening bacterial infections, is on the rise. In order to counter the threat of glycopeptide-resistant bacteria, we report development of a new class ...
Hoque, Jiaul; Konai, Mohini M.; Samaddar, Sandip; Gonuguntala, Spandhana; Manjunath, Goutham B.; Ghosh, Chandradhish; Haldar, Jayanta(Royal Society of Chemistry, 2015)
Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the ...
Ghosh, Chandradhish; Manjunath, Goutham B.; Konai, Mohini M.; Uppu, Divakara S. S. M.; Hoque, Jiaul; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta(Public Library Science, 2015)
Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of ...
Konai, Mohini M.; Haldar, Jayanta(American Chemical Society, 2015)
The emergence of bacterial resistance is a major threat to global health. Alongside this issue, formation of bacterial biofilms is another cause of concern because most antibiotics are ineffective against these recalcitrant ...
Konai, Mohini M.; Adhikary, Utsarga; Samaddar, Sandip; Ghosh, Chandradhish; Haldar, Jayanta(American Chemical Society, 2015)
The emergence of bacterial resistance and biofilm associated infections has created a challenging situation in global health. In this present state of affairs where conventional antibiotics are falling short of being able ...