• Membrane Active Vancomycin Analogues: A Strategy to Combat Bacterial Resistance 

  Yarlagadda, Venkateswarlu; Akkapeddi, Padma; Manjunath, Goutham B.; Haldar, Jayanta (American Chemical Society, 2014)

  The alarming growth of antibiotic resistant superbugs such as vancomycin-resistant Enterococci and Staphylococci has become a major global health hazard. To address this issue, we report the development of lipophilic ...
• Effect of amide bonds on the self-assembly of gemini surfactants 

  Hoque, Jiaul; Gonuguntla, Spandhana; Yarlagadda, Venkateswarlu; Aswal, Vinod K.; Haldar, Jayanta (Royal Society of Chemistry, 2014)

  This study provides an insight into the micellar aggregation properties in aqueous solutions of various gemini surfactants bearing one or more amide groups at the side chains and/or in the spacer by conductivity and small ...
• Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity 

  Konai, Mohini M.; Ghosh, Chandradhish; Yarlagadda, Venkateswarlu; Samaddar, Sandip; Haldar, Jayanta (American Chemical Society, 2014)

  Natural and synthetic membrane active antibacterial agents offer hope as potential solutions to the problem of bacterial resistance as the membrane-active nature imparts low propensity for the development of resistance. ...
• Isosteric substitution in cationic-amphiphilic polymers reveals an important role for hydrogen bonding in bacterial membrane interactions 

  Uppu, D. S. S. M.; Konai, M. M.; Baul, U.; Singh, P.; Siersma, T. K.; Samaddar, S.; Vemparala, S.; Hamoen, L. W.; Narayana, Chandrabhas; Haldar, Jayanta (Royal Society of Chemistry, 2016)

  Biomimetic antibacterial polymers, the functional mimics of antimicrobial peptides (AMPs), targeting the bacterial cell membrane have been developed to combat the problem of antibiotic resistance. Amphiphilicity, a balance ...
• AVancomycin Derivative with a Pyrophosphate-Binding Group: A Strategy to Combat Vancomycin-Resistant Bacteria 

  Yarlagadda, Venkateswarlu; Sarkar, Paramita; Samaddar, Sandip; Haldar, Jayanta (Wiley-V C H Verlag Gmbh, 2016)

  Vancomycin, the drug of last resort for Gram-positive bacterial infections, has also been rendered ineffective by the emergence of resistance in such bacteria. To combat the threat of vancomycin-resistant bacteria (VRB), ...
• Antibacterial and Antibiofilm Activity of Cationic Small Molecules with Spatial Positioning of Hydrophobicity: An in Vitro and in Vivo Evaluation 

  Hoque, Jiaul; Konai, Mohini M.; Sequeira, Shanola S.; Samaddar, Sandip; Haldar, Jayanta (American Chemical Society, 2016)

  More than 80% of the bacterial infections are associated with biofilm formation. To combat infections, amphiphilic small molecules have been developed as promising antibiofilm agents. However, cytotoxicity of such molecules ...
• A Biodegradable Polycationic Paint that Kills Bacteria in Vitro and in Vivo 

  Hoque, Jiaul; Akkapeddi, Padma; Ghosh, Chandradhish; Uppu, Divakara S. S. M.; Haldar, Jayanta (American Chemical Society, 2016)

  Bacterial colonization and subsequent formation of biofilms onto surfaces of medical devices and implants is a major source of nosocomial infections. Most antibacterial coatings to combat infections are either metal-based ...
• Glycopeptide Antibiotic To Overcome the Intrinsic Resistance of Gram-Negative Bacteria 

  Yarlagadda, Venkateswarlu; Manjunath, Goutham B.; Sarkar, Paramita; Akkapeddi, Padma; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Ravikumar, Raju; Haldar, Jayanta (American Chemical Society, 2016)

  The emergence of drug resistance along with a declining pipeline of clinically useful antibiotics has made it vital to develop more effective antimicrobial therapeutics, particularly against difficult-to-treat Gram-negative ...
• Intracellular activity of a membrane-active glycopeptide antibiotic against meticillin-resistant Staphylococcus aureus infection 

  Yarlagadda, Venkateswarlu; Samaddar, Sandip; Haldar, Jayanta (Elsevier Sci Ltd, 2016)

  Staphylococcus aureus is a facultative intracellular pathogen and there are limited options for the treatment of severe intracellular bacterial infections. The membrane-active glycopeptide antibiotic Van-QC(8) is a permanent ...
• Aryl-alkyl-lysines: Membrane-Active Small Molecules Active against Murine Model of Burn Infection 

  Ghosh, Chandradhish; Manjunath, Goutham B.; Konai, Mohini M.; Uppu, Divakara S. S. M.; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Ravikumar, Raju; Haldar, Jayanta (American Chemical Society, 2016)

  Infections caused by drug-resistant Gramnegative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens, against which ...
• Designing Simple Lipidated Lysines: Bifurcation Imparts Selective Antibacterial Activity 

  Ghosh, Chandradhish; Konai, Mohini Mohan; Sarkar, Paramita; Samaddar, Sandip; Haldar, Jayanta (Wiley-V C H Verlag Gmbh, 2016)

  In the global effort to thwart antimicrobial resistance, lipopeptides are an important class of antimicrobial agents, especially against Gram-negative infections. In an attempt to circumvent their synthetic complexities, ...
• Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers 

  Uppu, D. S. S. M.; Bhowmik, M.; Samaddar, S.; Haldar, Jayanta (Royal Society of Chemistry, 2016)

  Membrane-active agents represent a promising alternative to overcome antibiotic resistance. Here, we report cationic-amphiphilic polymers with variations in the side chain architecture such as cyclization, isomerization ...
• Lipopolysaccharide Neutralization by Cationic-Amphiphilic Polymers through Pseudoaggregate Formation 

  Uppu, Divakara S. S. M.; Haldar, Jayanta (American Chemical Society, 2016)

  Synthetic polymers incorporating the cationic charge and hydrophobicity to mimic the function of antimicrobial peptides (AMPs) have been developed. These cationic-amphiphilic polymers bind to bacterial membranes that ...
• Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials 

  Hoque, Jiaul; Adhikary, Utsarga; Yadav, Vikas; Samaddar, Sandip; Konai, Mohini Mohan; Prakash, Relekar Gnaneshwar; Pararnanandham, Krishnamoorthy; Shome, Bibek R.; Sanyal, Kaustuv; Haldar, Jayanta (American Chemical Society, 2016)

  The continuous rise of antimicrobial resistance and the dearth of new antibiotics in the clinical pipeline raise an urgent call for the development of potent antimicrobial agents. Cationic chitosan derivatives, ...
• Membrane-Active Macromolecules Resensitize NDM-1 Gram-Negative Clinical Isolates to Tetracycline Antibiotics 

  Uppu, Divakara S. S. M.; Manjunath, Goutham B.; Yarlagadda, Venkateswarlu; Kaviyil, Jyothi E.; Ravikumar, Raju; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta (Public Library Science, 2015)

  Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (bla(NDM-1)) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old ...
• Membrane Disruption and Enhanced Inhibition of Cell-Wall Biosynthesis: A Synergistic Approach to Tackle Vancomycin-Resistant Bacteria 

  Yarlagadda, Venkateswarlu; Samaddar, Sandip; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta (Wiley-V C H Verlag Gmbh, 2015)

  Resistance to glycopeptide antibiotics, the drugs of choice for life-threatening bacterial infections, is on the rise. In order to counter the threat of glycopeptide-resistant bacteria, we report development of a new class ...
• Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms 

  Hoque, Jiaul; Konai, Mohini M.; Samaddar, Sandip; Gonuguntala, Spandhana; Manjunath, Goutham B.; Ghosh, Chandradhish; Haldar, Jayanta (Royal Society of Chemistry, 2015)

  Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the ...
• Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection 

  Ghosh, Chandradhish; Manjunath, Goutham B.; Konai, Mohini M.; Uppu, Divakara S. S. M.; Hoque, Jiaul; Paramanandham, Krishnamoorthy; Shome, Bibek R.; Haldar, Jayanta (Public Library Science, 2015)

  Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of ...
• Lysine-Based Small Molecules That Disrupt Biofilms and Kill both Actively Growing Planktonic and Nondividing Stationary Phase Bacteria 

  Konai, Mohini M.; Haldar, Jayanta (American Chemical Society, 2015)

  The emergence of bacterial resistance is a major threat to global health. Alongside this issue, formation of bacterial biofilms is another cause of concern because most antibiotics are ineffective against these recalcitrant ...
• Structure-Activity Relationship of Amino Acid Tunable Lipidated Norspermidine Conjugates: Disrupting Biofilms with Potent Activity against Bacterial Persisters 

  Konai, Mohini M.; Adhikary, Utsarga; Samaddar, Sandip; Ghosh, Chandradhish; Haldar, Jayanta (American Chemical Society, 2015)

  The emergence of bacterial resistance and biofilm associated infections has created a challenging situation in global health. In this present state of affairs where conventional antibiotics are falling short of being able ...

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