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Browsing Ravi Manjithaya by Issue Date

Browsing Ravi Manjithaya by Issue Date

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  • The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile 
    Kashi, Venkatesh P.; Jacob, Rajesh A.; Shamanna, Raghavendra A.; Menon, Malini; Balasiddaiah, Anangi; Varghese, Rebu K.; Bachu, Mahesh; Ranga, Udaykumar (Public Library of Science, 2014)
    Extracellular Tat (eTat) plays an important role in HIV-1 pathogenesis. The presence of anti-Tat antibodies is negatively correlated with disease progression, hence making Tat a potential vaccine candidate. The cytotoxicity ...
  • Reactivation of latent HIV-1 by new semi-synthetic ingenol esters 
    Jose, Diego Pandelo; Bartholomeeusen, Koen; da Cunha, Rodrigo Delvecchio; Abreu, Celina Monteiro; Glinski, Jan; Ferreira da Costa, Thais Barbizan; Mello Bacchi Rabay, Ana Flavia; Pianowski Filho, Luiz Francisco; Dudycz, Lech W.; Ranga, Udaykumar; Peterlin, Boris Matija; Pianowski, Luiz Francisco; Tanuri, Amilcar; Aguiar, Renato Santana (Academic Press Inc Elsevier Science, 2014)
    The ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent ...
  • Evaluation of chitosan nanoformulations as potent anti-HIV therapeutic systems 
    Ramana, Lakshmi Narashimhan; Sharma, Shilpee; Sethuraman, Swaminathan; Ranga, Udaykumar; Krishnan, Uma Maheswari (Elsevier Science Bv, 2014)
    Background: Antiretroviral Therapy (ART) is currently the major therapeutic intervention in the treatment of AIDS. ART, however, is severely limited due to poor availability, high cytotoxicity, and enhanced metabolism and ...
  • Synthesis of Hybrid Cyclic Peptoids and Identification of Autophagy Enhancer 
    Rajasekhar, Kolla; Narayanaswamy, Nagarjun; Mishra, Piyush; Suresh, S. N.; Manjithaya, Ravi; Govindaraju, T. (Wiley-V C H Verlag Gmbh, 2014)
    Cyclic peptoids are potential candidates for diverse biological activities. However, applications of cyclic peptoids are limited by the synthetic difficulties, conformational flexibility of large cyclic peptoids, and lack ...
  • Genetic Diversity in HIV-1 Subtype C LTR from Brazil and Mozambique Generates New Transcription Factor-Binding Sites 
    Boullosa, Jose; Bachu, Mahesh; Bila, Dulce; Ranga, Udaykumar; Sueffert, Theodoro; Sasazawa, Tomoko; Tanuri, Amilcar (Mdpi Ag, 2014)
    The HIV-1 subtype C has been substituting the subtype B population in southern Brazil. This phenomenon has been previously described in other countries, suggesting that subtype C may possess greater fitness than other ...
  • Rationally Designed Peptidomimetic Modulators of A beta Toxicity in Alzheimer's Disease 
    Rajasekhar, K.; Suresh, S. N.; Manjithaya, Ravi; Govindaraju, T. (Nature Publishing Group, 2015)
    Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21st century. The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the beta-amyloid (A beta) peptides into ...
  • Fluorescence microscopy: A tool to study autophagy 
    Rai, Shashank; Manjithaya, Ravi (American Institute of Physics, 2015)
    Autophagy is a cellular recycling process through which a cell degrades old and damaged cellular components such as organelles and proteins and the degradation products are reused to provide energy and building blocks. ...
  • Multispectral Bayesian reconstruction technique for real-time two color fluorescence microscopy 
    Dilipkumar, Shilpa; Manjithaya, Ravi; Mondal, Partha Pratim (Royal Society of Chemistry, 2015)
    We have developed a real-time imaging method for two-color wide-field fluorescence microscopy using a combined approach that integrates multi-spectral imaging and Bayesian image reconstruction technique. To enable simultaneous ...

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