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Now showing items 1-8 of 8

The Evolving Profile of the Signature Amino Acid Residues in HIV-1 Subtype C Tat

Aralaguppe, Shambhu Prasad G.; Sharma, Shilpee; Menon, Malini; Prasad, Vinayaka R.; Saravanan, Shanmugam; Murugavel, Kailapuri G.; Solomon, Suniti; Ranga, Udaykumar (Mary Ann Liebert, Inc, 2016)

Using several HIV-1 tat exon 1 amino acid sequences available from public databases and additional sequences derived from a southern Indian clinical cohort, we compared the profile of the signature amino acid residues (SAR) ...
Functional Incompatibility between the Generic NF-kappa B Motif and a Subtype-Specific Sp1III Element Drives the Formation of the HIV-1 Subtype C Viral Promoter

Verma, Anjali; Rajagopalan, Pavithra; Lotke, Rishikesh; Varghese, Rebu; Selvam, Deepak; Kundu, Tapas Kumar; Ranga, Udaykumar (American Society Microbiology, 2016)

Of the various genetic subtypes of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV), only in subtype C of HIV-1 is a genetically variant NF-kappa B binding site found at ...
Genetic diversity and proviral DNA load in different neural compartments of HIV-1 subtype C infection

Mishra, Mamata; Varghese, Rebu K.; Verma, Anjali; Das, Sutanuka; Aguiar, Renato Santana; Tanuri, Amilcar; Mahadevan, Anita; Shankar, Susarla K.; Satishchandra, Parthasarathy; Ranga, Udaykumar (Springer, 2015)

In India, the low prevalence of HIV-associated dementia (HAD) in the Human immunodeficiency virus type 1 (HIV-1) subtype C infection is quite paradoxical given the high-rate of macrophage infiltration into the brain. Whether ...
Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes

Dhanasekaran, Karthigeyan; Kumari, Sujata; Boopathi, Ramachandran; Shima, Hiroki; Swaminathan, Amrutha; Bachu, Mahesh; Ranga, Udaykumar; Igarashi, Kazuhiko; Kundu, Tapas Kumar (Wiley-Blackwell, 2016)

Positive coactivator 4 (PC4), a human transcriptional coactivator, is involved in diverse processes like chromatin organization and transcription regulation. It is hyperphosphorylated during mitosis, with unknown significance. ...
Simulating natural light and temperature cycles in the laboratory reveals differential effects on activity/rest rhythm of four Drosophilids

Prabhakaran, Priya M.; Sheeba, Vasu (Springer, 2014)

Recent studies under semi-natural conditions have revealed various unique features of activity/rest rhythms in Drosophilids that differ from those under standard laboratory conditions. An additional afternoon peak (A-peak) ...
Stealth anti-CD4 conjugated immunoliposomes with dual antiretroviral drugs - Modern Trojan horses to combat HIV

Ramana, Lakshmi Narashimhan; Sharma, Shilpee; Sethuraman, Swaminathan; Ranga, Udaykumar; Krishnan, Uma Maheswari (Elsevier Science Bv, 2015)

Highly active antiretroviral therapy (HAART) is the currently employed therapeutic intervention against AIDS where a drug combination is used to reduce the viral load. The present work envisages the development of a stealth ...
Temperature sensitivity of circadian clocks is conserved across Drosophila species melanogaster, malerkotliana and ananassae

Prabhakaran, Priya M.; Sheeba, Vasu (Informa Healthcare, 2014)

Light and temperature are the major environmental cycles that can synchronize circadian rhythms in a variety of organisms. Previously, we have shown that under light/dark cycles of various photoperiods, the Drosophila ...
Toll-Like Receptor 9 Activation Rescues Impaired Antibody Response in Needle-free Intradermal DNA Vaccination

Arunachalam, Prabhu S.; Mishra, Ria; Badarinath, Krithika; Selvam, Deepak; Payeli, Sravan K.; Stout, Richard R.; Ranga, Udaykumar (Nature Publishing Group, 2016)

The delivery of plasmid DNA to the skin can target distinct subsets of dermal dendritic cells to confer a superior immune response. The needle-free immunization technology offers a reliable, safe and efficient means to ...

Now showing items 1-8 of 8

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