Circadian disturbances are early features of neurodegenerative diseases, including Huntington’s Disease (HD). Emerging evidence suggests that circadian decline feeds into neurodegenerative symptoms, exacerbating them. ...
Lakshman, Abhilash(Jawaharlal Nehru Centre for Advanced Scientific ResearchNeuroscience Unit (NSU), 2020)
The concept of ‘time’ has been of profound interest and a topic of debate, with deep roots in religion and philosophy, from ancient times to the present day. Some philosophers have even dismissed time as being a mental ...
Vishwanath, Anjali Amrapali(Jawaharlal Nehru Centre for Advanced Scientific ResearchNSU, 2018)
Proper functioning of complex systems depends on the precise and apt coordination of its components at multiple levels. A failure in this can lead to aberrant systemic functioning. One such complex system which requires ...
Kundu, Pritha(Jawaharlal Nehru Centre for Advanced Scientific ResearchNeuroscience Unit, 2017)
For centuries, it has been observed that behavioral and physiological processes of most organisms occur in a rhythmic manner with different periodicities (see Daan, 2010). Trees flower and fruit at species-specific seasons ...
Roy, Saheli(Jawaharlal Nehru Centre for Advanced Scientific ResearchNSU, 2019)
What is sleep? Sleep is a state of behavioral quiescence with reduced sensory responsiveness. From the simple cnidarian, jelly-fish to human beings, sleep has been found to be a conserved behavior in the metazoan world ...
Paul, Abhik(Jawaharlal Nehru Centre for Advanced Scientific ResearchNSU, 2019)
The ancient Egyptians were the first known people to use the word 'Brain' when they mentioned about
some of the “head-related” illnesses in the papyrus scriptures. Strangely, they used to believe that the
heart is the ...
Sharma, Ankit(Jawaharlal Nehru Centre for Advanced Scientific ResearchNSU, 2019)
Neurodegenerative diseases (NDs) are incurable debilitating conditions that affect millions of people worldwide. These diseases are becoming more common because of increased life span and changing population demographics. ...
In fruit flies Drosophila melanogaster, environmental cycles of light and temperature are known to influence behavioral rhythms through dedicated sensory receptors. But the thermosensory pathways and molecular receptors ...
Jeyabalan, Nallathambi; Chelliah, James P. C.(Frontiers Media Sa, 2016)
A cardinal feature of early stages of human brain development centers on the sensory, cognitive, and emotional experiences that shape neuronal-circuit formation and refinement. Consequently, alterations in these processes ...
Gogna, Navdeep; Singh, Viveka Jagdish; Sheeba, Vasu; Dorai, Kavita(Royal Society of Chemistry, 2015)
We utilized an NMR-based metabolomic approach to profile the metabolites in Drosophila melanogaster that cycle with a daily rhythm. H-1 1D and 2D NMR experiments were performed on whole-body extracts sampled from flies ...
Daily rhythms in Drosophila under semi-natural conditions (or SN) have received much recent attention. One of the striking differences in the behaviour of wild type flies under SN is the presence of an additional peak of ...