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Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties

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dc.contributor.author Avinash, M. B.
dc.contributor.author Raut, Devaraj
dc.contributor.author Mishra, Manish Kumar
dc.contributor.author Ramamurty, Upadrasta
dc.contributor.author Govindaraju, T.
dc.date.accessioned 2017-01-04T09:07:36Z
dc.date.available 2017-01-04T09:07:36Z
dc.date.issued 2015
dc.identifier.citation Scientific Reports en_US
dc.identifier.citation 5 en_US
dc.identifier.citation Avinash, M. B.; Raut, D.; Mishra, M. K.; Ramamurty, U.; Govindaraju, T., Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties. Scientific Reports 2015, 5, 8. en_US
dc.identifier.issn 2045-2322
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2001
dc.description Restricted access en_US
dc.description.abstract A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was utilized to synthesize molecular crystals of cyclic dipeptides (CDPs), whose molecular weights (similar to 0.2 kDa) are nearly three orders of magnitude smaller than that of natural structural proteins (50-300 kDa). Mechanical properties of these materials, measured using the nanoindentation technique, indicate that the stiffness and strength are comparable and sometimes better than those of natural fibres. The measured mechanical responses were rationalized by recourse to the crystallographic structural analysis and intermolecular interactions in the self-assembled single crystals. With this work we highlight the significance of developing small molecule based bioinspired design strategies to emulate biomechanical properties. A particular advantage of the successfully demonstrated reductionistic strategy of the present work is its amenability for realistic industrial scale manufacturing of designer biomaterials with desired mechanical properties. en_US
dc.description.uri http://dx.doi.org/10.1038/srep16070 en_US
dc.language.iso English en_US
dc.publisher Nature Publishing Group en_US
dc.rights ?Nature Publishing Group, 2015 en_US
dc.subject Molecular-Crystals en_US
dc.subject Nanoindentation en_US
dc.subject Strength en_US
dc.subject Design en_US
dc.title Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties en_US
dc.type Article en_US


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