DSpace Repository

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

Show simple item record

dc.contributor.author Rajasekhar, K.
dc.contributor.author Chakrabarti, Malabika
dc.contributor.author Govindaraju, T.
dc.date.accessioned 2017-01-04T09:07:36Z
dc.date.available 2017-01-04T09:07:36Z
dc.date.issued 2015
dc.identifier.citation Chemical Communications en_US
dc.identifier.citation 51 en_US
dc.identifier.citation 70 en_US
dc.identifier.citation Rajasekhar, K.; Chakrabarti, M.; Govindaraju, T., Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease. Chemical Communications 2015, 51 (70), 13434-13450. en_US
dc.identifier.issn 1359-7345
dc.identifier.uri https://libjncir.jncasr.ac.in/xmlui/10572/2004
dc.description Restricted access en_US
dc.description.abstract Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one of the most devastating ailments among amyloidogenesis induced dementia. The amyloid beta (A beta) peptide derived from amyloid precursor protein (APP) is misfolded and deposited as plaques in the brain, which are said to be the hallmark of Alzheimer's disease. In normal brains physiological concentration of the A beta peptide has been indicated to be involved in modulating neurogenesis and synaptic plasticity. However, excess A beta production, its aggregation and deposition deleteriously affect a large number of biologically important pathways leading to neuronal cell death. Targeting A beta production, A beta aggregation or its clearance from the brain has been an active area of research for preventing or curing AD. Our Feature Article intends to detail the aggregation mechanism, the physiological role of the A beta peptide, elaborate its toxic effects, and outline the different classes of molecules designed in the last two years to inhibit amyloidogenic APP processing, A beta oligomerization or fibrillogenesis and to modulate different pathways for active clearance of A beta from the brain. en_US
dc.description.uri 1364-548X en_US
dc.description.uri http://dx.doi.org/10.1039/c5cc05264e en_US
dc.language.iso English en_US
dc.publisher Royal Society of Chemistry en_US
dc.rights ?Royal Society of Chemistry, 2015 en_US
dc.subject Chemistry en_US
dc.subject Gamma-Secretase Modulators en_US
dc.subject Solid-State NMR en_US
dc.subject Metal Chelation-Therapy en_US
dc.subject 1 Bace1 Inhibitors en_US
dc.subject Neural Stem-Cells en_US
dc.subject A-Beta en_US
dc.subject Neurodegenerative Diseases en_US
dc.subject Precursor Protein en_US
dc.subject Small-Molecule en_US
dc.subject Synaptic Plasticity en_US
dc.title Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account