Browsing Nagaraja, V. by Author "Ahmed, Wareed"

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Autoregulation of topoisomerase I expression by supercoiling sensitive transcription

Ahmed, Wareed; Menon, Shruti; Karthik, Pullela V. D. N. B.; Nagaraja, Valakunja (Oxford University Press, 2016)

The opposing catalytic activities of topoisomerase I (TopoI/relaxase) and DNA gyrase (supercoiling enzyme) ensure homeostatic maintenance of bacterial chromosome supercoiling. Earlier studies in Es-cherichia coli suggested ...
Conditional silencing of topoisomerase I gene of Mycobacterium tuberculosis validates its essentiality for cell survival

Ahmed, Wareed; Menon, Shruti; Godbole, Adwait Anand; Karthik, Pullela V. D. N. B.; Nagaraja, V. (Oxford University Press, 2014)

Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic ...
Inhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poison

Godbole, Adwait Anand; Ahmed, Wareed; Bhat, Rajeshwari Subray; Bradley, Erin K.; Ekins, Sean; Nagaraja, V. (Academic Press Inc Elsevier Science, 2014)

m-AMSA, an established inhibitor of eukaryotic type II topoisomerases, exerts its cidal effect by binding to the enzyme-DNA complex thus inhibiting the DNA religation step. The molecule and its analogues have been successfully ...

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